Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment

Gullner, Hans-Georg, Graf, Andrew K. and Mitchell, Murray D. (1983) Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment. Prostaglandins Leukotrienes and Medicine, 12 2: 119-123. doi:10.1016/0262-1746(83)90075-6


Author Gullner, Hans-Georg
Graf, Andrew K.
Mitchell, Murray D.
Title Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment
Journal name Prostaglandins Leukotrienes and Medicine   Check publisher's open access policy
ISSN 0262-1746
Publication date 1983-10
Sub-type Article (original research)
DOI 10.1016/0262-1746(83)90075-6
Volume 12
Issue 2
Start page 119
End page 123
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain) which are devoid of vasopressin, excrete significantly increased amounts of immunoreactive thromboxane B2 in urine. The increase was corrected by treatment with vasopressin. These results suggest that, in the intact organism, thromboxane synthesis may be under tonic inhibitory control by vasopressin although other renal mechanisms explaining the increase in thromboxane cannot be excluded. Our observations further support an involvement of prostaglandins and thromboxanes in the regulation of water metabolism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:53:27 EST