PGE2 and 6-keto-PGF(1α) excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus

Gullner, H.G., Graf, A.K. and Mitchell, M.D. (1983) PGE2 and 6-keto-PGF(1α) excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Archives Internationales de Pharmacodynamie et de Therapie, 266 1: 17-22.

Author Gullner, H.G.
Graf, A.K.
Mitchell, M.D.
Title PGE2 and 6-keto-PGF(1α) excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus
Formatted title
PGE2 and 6-keto-PGF(1α) excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus

Journal name Archives Internationales de Pharmacodynamie et de Therapie   Check publisher's open access policy
ISSN 0003-9780
Publication date 1983
Sub-type Article (original research)
Volume 266
Issue 1
Start page 17
End page 22
Total pages 6
Place of publication Bruxelles
Publisher Office Internationale de Libraire
Language eng
Subject 1103 Clinical Sciences
110306 Endocrinology
Formatted abstract
Brattleboro rats, a strain with hereditary hypothalamic diabetes insipidus, were found to excrete significantly higher amounts of both renal (PGE2) and vascular (6-keto-PGF(1α)) prostaglandins than control Long-Evans rats. The increased prostaglandin synthesis was reversed by vasopression treatment. These results suggest that in the intact organism prostaglandin synthesis in the kidneys and in the endothelial cells of blood vessels may be under tonic inhibitory control by vasopression. The findings further support the view that prostaglandins play an important role in regulation of water excretion and in the pathogenesis of polyuric conditions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:53:24 EST