Effect of radiation on prostaglandin production by human bowel in vitro

Gal, David, Strickland, Daniel M., Lifshitz, Samuel, Buchcbaum, Herbert J. and Mitchell, Murray D. (1984) Effect of radiation on prostaglandin production by human bowel in vitro. International Journal of Radiation Oncology Biology Physics, 10 5: 653-657. doi:10.1016/0360-3016(84)90296-7

Author Gal, David
Strickland, Daniel M.
Lifshitz, Samuel
Buchcbaum, Herbert J.
Mitchell, Murray D.
Title Effect of radiation on prostaglandin production by human bowel in vitro
Journal name International Journal of Radiation Oncology Biology Physics   Check publisher's open access policy
ISSN 0360-3016
Publication date 1984-04
Sub-type Article (original research)
DOI 10.1016/0360-3016(84)90296-7
Volume 10
Issue 5
Start page 653
End page 657
Total pages 5
Place of publication Tarrytown, N.Y., USA
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1112 Oncology and Carcinogenesis
Formatted abstract
The effect of gamma irradiation on the production of prostaglandins by human colon was investigated. Squares of tissue in organ culture dishes were irradiated with 500, 1000, or 2500 rad in single applications. Tissues that were not irradiated served as controls. After treatment the tissues were superfused and prostaglandin concentrations in the effluent fluid were determined. The rates of production of prostaglandins E2 and F2(α) by irradiated tissues were significantly lower (p <0.05) than those of nonirradiated tissues. Neither the release of lactate dehydrogenase nor the rate of production of 13,14-dihydro-15-keto-prostaglandin F2(α) were increased in the irradiated samples, suggesting that neither decreased cell viability nor increased prostaglandin metabolism accounted for the decreased prostaglandin production rates. We conclude that irradiation of the human colon in vitro results in an acute inhibition of prostaglandin synthesis. The cytoprotective nature of prostaglandins is discussed with regard to the possible pathophysiological significance of these findings.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 12:52:55 EST