Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at. 125-143 days' gestation in the pregnant sheep

El Badry, A., Figueroa, J. P., Poore, E. R., Sunderji, S., Levine, S., Mitchell, M. D. and Nathanielsz , P. W. (1984) Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at. 125-143 days' gestation in the pregnant sheep. American Journal of Obstetrics and Gynecology, 150 5: 474-479.

Author El Badry, A.
Figueroa, J. P.
Poore, E. R.
Sunderji, S.
Levine, S.
Mitchell, M. D.
Nathanielsz , P. W.
Title Effect of fetal intravascular 4-aminoantipyrine infusions on myometrial activity (contractures) at. 125-143 days' gestation in the pregnant sheep
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 1984
Sub-type Article (original research)
Volume 150
Issue 5
Start page 474
End page 479
Total pages 6
Place of publication St. Louis, Mo. U.S.A.
Publisher Mosby
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract Myometrial activity of low amplitude and long duration--contractures--is present throughout gestation in the pregnant ewe and other species. This activity differs from the contractions of labor and delivery. Between 125 and 143 days' gestation, 4-aminoantipyrine infused into the fetus at rates that produced maternal uterine vein plasma concentrations of 4-aminoantipyrine of 5.95 +/- 1.23 (mean +/- SEM, n = 5) mg X 100 ml-1 markedly depressed both total myometrial electromyographic activity to 28.6% and frequency of contractures to 30.5% of preinfusion values. By 60 minutes of infusion, maternal uterine vein plasma 13,14-dihydro-15-keto prostaglandin F2 alpha concentration was reduced to 14% of the resting level. Two conclusions were drawn from this study. First, prostaglandins are involved in the regulation of contractures. Second, when infusions of 4-aminoantipyrine are used to quantify uterine or umbilical blood flow, the possibility exists that changes will occur in physiologic systems that are modified by prostaglandins.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:52:13 EST