Elevation of amniotic fluid interleukin-4 concentrations in women with preterm labor and chorioamnionitis

Dudley, D.J., Hunter, C., Varner, M.W. and Mitchell, M.D. (1996) Elevation of amniotic fluid interleukin-4 concentrations in women with preterm labor and chorioamnionitis. American Journal of Perinatology, 13 7: 443-447. doi:10.1055/s-2007-994385


Author Dudley, D.J.
Hunter, C.
Varner, M.W.
Mitchell, M.D.
Title Elevation of amniotic fluid interleukin-4 concentrations in women with preterm labor and chorioamnionitis
Journal name American Journal of Perinatology   Check publisher's open access policy
ISSN 0735-1631
Publication date 1996-10
Sub-type Article (original research)
DOI 10.1055/s-2007-994385
Volume 13
Issue 7
Start page 443
End page 447
Total pages 5
Place of publication New York, N.Y. U.S.A.
Publisher Thieme Medical Publishers
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
1115 Pharmacology and Pharmaceutical Sciences
Abstract Preterm labor associated with intrauterine infection is characterized by increased amniotic fluid concentrations of various proinflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (THF-α), (IL- 6, IL-8, and macrophage inflammatory protein-1α (MIP-1α). The purpose of this study was to determine if preterm labor in women with clinically evident chorioamnionitis is marked by elevations of the anti-inflammatory cytokine interleukin-4 (IL-4) and the T cell growth factor IL-2. Amniotic fluid samples were obtained from (1) women at term, not in labor (n = 10); (2) women at term, in labor (n = 10); (3) women with preterm contractions but undelivered within 1 week of amniotic fluid collection (n = 10); (4) women with preterm labor and delivery without clinically evident chorioamnionitis (n = 10); (5) women with preterm labor associated with chorioamnionitis (n = 8); and (6) women with preterm labor and delivery without matched with patients with chorioamnionitis (=8). Amniotic fluid concentrations of IL-4 and IL-2 were determined for each sample with a specific and sensitive enzyme-liked immunoassay. We found that women with infection-associated preterm labor and delivery had significantly higher concentration of IL-4 when compared to appropriately matched controls (p < 0.05). Additionally, women with preterm labor and delivery not associated with infection had higher amniotic fluid IL-4 concentrations than women with preterm contractions but no labor (p < 0.05). Women with term labor had rare modest elevations of amniotic fluid IL-4. No IL-2 was detected in any sample. Our data indicate that amniotic fluid IL-4 is elevated in women with preterm labor and delivery, particularly in association with chorioamnionitis. We suggest that IL-4, although previously considered an anti-inflammatory agent, may have a paradoxical proinflammatory role in the pathogenesis of infection- associated preterm labor.
Keyword interleukin-4
Preterm Labor
Chorioamnionitis
Amniotic fluid
Tumor necrosis factor
Human-Fetal Membranes
Prostaglandin Biosynthesis
Intraamniotic Infection
Inflammatory Mediators
Decidual Interface
Cells
Term
Parturition
Management
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 37 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 26 Aug 2010, 12:51:16 EST