Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor

Dudley, D.J., Hunter, C., Mitchell, M.D. and Varner, M.W. (1996) Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor. Obstetrics and Gynecology, 87 1: 94-98. doi:10.1016/0029-7844(95)00366-5


Author Dudley, D.J.
Hunter, C.
Mitchell, M.D.
Varner, M.W.
Title Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor
Journal name Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0029-7844
Publication date 1996-01
Sub-type Article (original research)
DOI 10.1016/0029-7844(95)00366-5
Volume 87
Issue 1
Start page 94
End page 98
Total pages 5
Place of publication New York, N.Y. U.S.A.
Publisher American College of Obstetricians and Gynecologists
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objective:
To determine whether elevated concentrations of macrophage inflammatory protein-1α (MIP-1α) in amniotic fluid (AF) are related to term and preterm labor.

Methods:
Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor (n = 29); 2) normal term labor, no infection (n = 36); 3) preterm labor, delivery more than 1 week from sampling, no infection (n = 19); 4) preterm labor, delivery within 1 week from sampling, no infection (n = 18); and 5) preterm chorioamnionitis (n = 8). Amniotic fluid was collected aseptically at the time of amniocentesis, amniotomy, or hysterotomy. Concentrations of MIP-1α were determined by enzyme-linked immunosorbent assay. Statistical analysis was by Wilcoxon rank-sum test, Kruskal-Wallis test, and unpaired t test.

Results:
Women in normal term labor had significant elevations of AF MIP-1α concentrations when compared with women at term undergoing repeat cesarean delivery (P < .001). In women with term gestation, AF MIP-1α correlated well with cervical dilation (r2 = 0.479, P < .001). In women with preterm labor who later delivered within 1 week of presentation, AF MIP-1α concentrations were higher than those from women who did not deliver within 1 week. Women who presented with clinically evident chorioamnionitis had the highest concentrations of AF MIP-1α (P = .001).

Conclusion:

Women in labor have significantly elevated AF concentrations of MIP-1α, particularly if labor is associated with intrauterine infection. We suggest that MIP-1α is involved in the physiology of normal labor and in the pathogenesis of infection- associated preterm labor.
Keyword Histologic Chorioamnionitis
Interleukin -8 Production
Human Parturition
Intact Membranes
Premature labor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 26 Aug 2010, 12:51:08 EST