Isolation of multiple substances in amniotic fluid that regulate amnion prostaglandin E2 production: the effects of gestational age and labor

Dowling, D.D., Romero, R.J., Mitchel, M.D. and Lundin-Schiller, S. (1991) Isolation of multiple substances in amniotic fluid that regulate amnion prostaglandin E2 production: the effects of gestational age and labor. Prostaglandins Leukotrienes and Essential Fatty Acids, 44 4: 253-255. doi:10.1016/0952-3278(91)90026-2


Author Dowling, D.D.
Romero, R.J.
Mitchel, M.D.
Lundin-Schiller, S.
Title Isolation of multiple substances in amniotic fluid that regulate amnion prostaglandin E2 production: the effects of gestational age and labor
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 1991-12
Sub-type Article (original research)
DOI 10.1016/0952-3278(91)90026-2
Volume 44
Issue 4
Start page 253
End page 255
Total pages 3
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
The present study was undertaken to evaluate the effects of whole amniotic fluid (AF) and fractions of AF on amnion cell prostaglandin E2 (PGE2)production. Amnion cells were grown to confluence and then incubated in the presence of AF, or fractions thereof, obtained at 17-19 weeks gestation (MID), at term prior to the onset of labor (NIL), and at term after spontaneous onset of labor (LABOR). All whole AFs were stimulatory to amnion cell PGE2 production (p < 0.001) but the stimulation by NIL and LABOR AFs was significantly greater (p < 0.001) than stimulation by the MID AF. Fractionation of the AFs from the three groups (n = 9 - 10 per group) revealed multiple discernable peaks of stimulatory activity in each group. The majority of peaks had retention times that were similar among the three groups, and peak stimulatory activities were greater in NIL and LABOR samples than in MID samples.

Language of original document
Keyword Intrauterine Tissues
Cells
Stimulation
Culture
Biosynthesis
Parturition
Urine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:50:38 EST