Bartter's syndrome: 10 cases in childhood. Results of long term indomethacin therapy

Dillon, M.J., Shah, V. and Mitchell, M.D. (1979) Bartter's syndrome: 10 cases in childhood. Results of long term indomethacin therapy. Quarterly Journal of Medicine, 48 3: 429-446.


Author Dillon, M.J.
Shah, V.
Mitchell, M.D.
Title Bartter's syndrome: 10 cases in childhood. Results of long term indomethacin therapy
Journal name Quarterly Journal of Medicine   Check publisher's open access policy
ISSN 0033-5622
1460-2393
Publication date 1979-07
Sub-type Article (original research)
Volume 48
Issue 3
Start page 429
End page 446
Total pages 18
Place of publication Oxford, England
Publisher Clarendon Press
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Ten children with Bartter's syndrome are described. Their ages at diagnosis ranged from three months to 15 years and there was an equal sex distribution. A wide spectrum of severity of clinical and biochemical features was found. Hypercalcaemia, hypophosphataemia, hypercalcuria, nephrocalcinosis, rickets and urine acidification defects were seen in some patients. Two affected children were siblings. Six children were treated over periods of six to 24 months with indomethacin with remarkable clinical and biochemical improvement. Catch-up growth was demonstrated in all treated cases. Tolerance to indomethacin appeared to develop in some children. Only one serious complication was seen with this therapy, a duodenal ulcer in a child on high dosage. Of those children not treated with indomethacin, one died, one is now on indomethacin elsewhere and two are well without therapy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:50:33 EST