Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1 beta, IL-6 and IL-8 with fetal fibronectin and cervical dilatation

Coleman, M.A.G., Keelan, J.A., McCowan, L.M.E., Townend, K.M. and Mitchell, M.D. (2001) Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1 beta, IL-6 and IL-8 with fetal fibronectin and cervical dilatation. European Journal of Obstetrics Gynecology and Reproductive Biology, 95 2: 154-158. doi:10.1016/S0301-2115(00)00450-4


Author Coleman, M.A.G.
Keelan, J.A.
McCowan, L.M.E.
Townend, K.M.
Mitchell, M.D.
Title Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1 beta, IL-6 and IL-8 with fetal fibronectin and cervical dilatation
Journal name European Journal of Obstetrics Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0301-2115
1872-7654
Publication date 2001-04-01
Sub-type Article (original research)
DOI 10.1016/S0301-2115(00)00450-4
Volume 95
Issue 2
Start page 154
End page 158
Total pages 5
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Objective:
To compare the cervicovaginal cytokines IL-1β, IL-6 and IL-8 with fetal fibronectin (fFN) and cervical dilatation in the prediction of preterm delivery.

Study design:
Cervicovaginal cytokine concentration and fFN status were measured in 104 women with symptoms of preterm labour and intact membranes between 240 and 336 weeks and related to delivery within 2 and 7 days.

Results:

A group of 18% had cervical dilatation≥1cm and 18% were positive for fFN. Preterm delivery within 2 and 7 days occurred in 5 and 12%, respectively. Only IL-6 demonstrated any ability to predict delivery within 2 and 7 days (area under the ROC curve=0.63 and 0.75, respectively). Using 35pg/ml (75th centile) as a cut-off, IL-6 had a sensitivity and specificity of 60 and 77% for predicting delivery within 2 days, and 62 and 80% for predicting delivery within 7 days. This is similar to the performance of cervical dilatation or fFN status.

Conclusions:

Measurement of cervicovaginal cytokines has limited ability to predict imminent delivery apart from cervicovaginal IL-6 concentrations, which, in this population, is equivalent to that of fFN status and cervical dilatation≥1cm. Copyright © 2001 Elsevier Science Ireland Ltd.
Keyword Cervicovaginal cytokines
Preterm labour
Preterm delivery
Tumor-necrosis-factor
Amniotic-fluid
Intact Membranes
Intrauterine Infection
Human-pregnancy
Genital-tract
Labor
Term
Parturition
Secretions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 22:49:34 EST