Prostaglandin synthesis inhibition by maternal and fetal sheep plasma and its relation to haptoglobin and albumin levels

Brennecke, S.P., Collier, H.O.J., Denning-Kendall, P.A., McDonald-Gibson, W.J., Saeed, S.A. and Mitchell, M.D. (1981) Prostaglandin synthesis inhibition by maternal and fetal sheep plasma and its relation to haptoglobin and albumin levels. Prostaglandins and Medicine, 6 2: 243-248. doi:10.1016/0161-4630(81)90096-3


Author Brennecke, S.P.
Collier, H.O.J.
Denning-Kendall, P.A.
McDonald-Gibson, W.J.
Saeed, S.A.
Mitchell, M.D.
Title Prostaglandin synthesis inhibition by maternal and fetal sheep plasma and its relation to haptoglobin and albumin levels
Journal name Prostaglandins and Medicine   Check publisher's open access policy
ISSN 0161-4630
Publication date 1981-02-01
Sub-type Article (original research)
DOI 10.1016/0161-4630(81)90096-3
Volume 6
Issue 2
Start page 243
End page 248
Total pages 6
Place of publication New York, N.Y. U.S.A.
Publisher Churchill Livingstone
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Mammalian plasmas and sera have been reported to contain endogenous inhibitors of prostaglandin synthesis (EIPS), but the identity and role of these suggested inhibitors is as yet undetermined. Albumin and haptoglobin have been proposed as possible inhibitors, and it has been suggested that EIPS may have a part to play in the control of PG production during pregnancy and in the neonatal period. As part of a series of studies aimed at elucidating the identity and role of EIPS, maternal and fetal blood samples were collected from chronically catheterized pregnant ewes, and plasma levels of albumin, haptoglobin and EIPS activity determined. Pregnant ewe plasma possessed high EIPS activity and fetal lamb plasma little or no EIPS activity. Levels of albumin and/or haptoglobin did not consistently parallel that of EIPS activity. A post-operative rise (4 sheep studied) and a pre-parturition nadir (1 sheep studied) in maternal plasma EIPS activity were also noted. The possible physiological significance of these results is discussed.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 22:48:27 EST