Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein

Branch, D. W., Mitchell, M. D., Miller, E., Palinski, W. and Witztum, J. L. (1994) Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein. Lancet, 343 8898: 645-646. doi:10.1016/S0140-6736(94)92639-5


Author Branch, D. W.
Mitchell, M. D.
Miller, E.
Palinski, W.
Witztum, J. L.
Title Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
1474-547X
Publication date 1994-03-12
Sub-type Other
DOI 10.1016/S0140-6736(94)92639-5
Volume 343
Issue 8898
Start page 645
End page 646
Total pages 2
Place of publication London, England
Publisher Lancet Publishing Group
Language eng
Subject 1114 Paediatrics and Reproductive Medicine
Abstract Oxidised low-density lipoprotein (Ox-LDL) has been associated with arterial foam-cell formation, and autoanti bodies to Ox-LDL are present in human serum. Lipid peroxidation is enhanced in pre-eclampsia. We assessed whether the titre of IgG autoantibody to an epitope of Ox-LDL, malondialdehyde- conjugated low-density lipoprotein (MDA-LDL), was increased in the sera of pre-eclamptic patients. 16 such patients had significantly higher mean titres of autoantibodies to MDA-LDL than healthy pregnant women (p=0·028). In a multiple regression model, pre-eclamptic patients still had a significantly higher mean titre (p=0·048). Enhanced lipid peroxidation may be involved in the foam-cell formation of decidua and in the pathogenesis of pre-eclampsia.
Keyword Pregnancy
Preeclampsia
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:48:16 EST