Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells

Branch, D.W., Dudley, D.J., LaMarche, S. and Mitchell, M.D. (1992) Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells. Prostaglandins Leukotrienes and Essential Fatty Acids, 45 3: 191-195. doi:10.1016/0952-3278(92)90112-V


Author Branch, D.W.
Dudley, D.J.
LaMarche, S.
Mitchell, M.D.
Title Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 1992-03
Sub-type Article (original research)
DOI 10.1016/0952-3278(92)90112-V
Volume 45
Issue 3
Start page 191
End page 195
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract A relative decrease in endothelial cell prostacyclin production may be pivotal in the genesis of preeclampsia. We determined the effect of sera from preeclamptic women on prostacyclin production by monolayers of normal term human umbilical vein endothelial cells. Endothelial cells were incubated with media containing serum from patients with preeclampsia, non-hypertensive, gestational age-matched pregnant controls, or normal non-pregnant controls (N = 7, all groups). 6-Keto-prostaglandin F(1α), the stable metabolite of prostacyclin, was measured directly in the culture medium by radioimmunoassay. Treatment with preeclamptic sera, when associated with a statistically significant increase in prostacyclin metabolite production by endothelial cells. Thus, sera from women with preeclampsia stimulate rather than inhibit prostacyclin production by endothelial cells. We speculate that there is a factor in the sera of women with preeclampsia that functions to activate endothelial cells or which may play a role in the homeostatic mechanisms to balance reduced prostacyclin output in preeclampsia.
Keyword Pregnancy-Induced Hypertension
Arachidonic-Acid Metabolites
Low-dose Aspirin
Vascular Prostacyclin
pre-eclampsia
Placental Prostacyclin
Thromboxane
Platelets
Fetal
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:48:09 EST