Cytokines of the placenta and extra-placental membranes: Biosynthesis, secretion and roles in establishment of pregnancy in women

Bowen, J. M., Chamley, L., Mitchell, M. D. and Keelan, J. A. (2002) Cytokines of the placenta and extra-placental membranes: Biosynthesis, secretion and roles in establishment of pregnancy in women. Placenta, 23 4: 239-256. doi:10.1053/plac.2001.0781


Author Bowen, J. M.
Chamley, L.
Mitchell, M. D.
Keelan, J. A.
Title Cytokines of the placenta and extra-placental membranes: Biosynthesis, secretion and roles in establishment of pregnancy in women
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2002-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1053/plac.2001.0781
Volume 23
Issue 4
Start page 239
End page 256
Total pages 18
Place of publication London, England
Publisher Human Gestational Tissue
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Virtually all known cytokines have been demonstrated to be expressed in the placenta and associated fetal and maternal membranes during normal gestation. In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental membranes, together with other locally-derived growth factors, appear to be implicated in various aspects of implantation and placental development. Imbalances in the intrauterine cytokine milieu around the time of implantation and invasion may play a causative role in disorders associated with early pregnancy failure, and are also associated with the abnormal trophoblast development seen in gestational trophoblastic disease. Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy.
Keyword Colony-stimulating Factor
Leukemia Inhibitory Factor
Transforming-Growth-Factor
Tumor-necrosis-factor
Interleukin-1 Receptor Antagonist
Recurrent Spontaneous-Abortion
Polymerase-chain-reaction
Monocyte chemotactic protein-1
Human Extravillous Trophoblast
Human Gestational Tissues
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:47:48 EST