Suppressors of cytokine signaling proteins in human preterm placental tissues

Blumenstein, M., Keelan, J. A., Bowen-Shauver, J. M. and Mitchell, M. D. (2005) Suppressors of cytokine signaling proteins in human preterm placental tissues. Journal Of Molecular Endocrinology, 35 1: 165-175. doi:10.1677/jme.1.01767

Author Blumenstein, M.
Keelan, J. A.
Bowen-Shauver, J. M.
Mitchell, M. D.
Title Suppressors of cytokine signaling proteins in human preterm placental tissues
Journal name Journal Of Molecular Endocrinology   Check publisher's open access policy
ISSN 1479-6813
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1677/jme.1.01767
Volume 35
Issue 1
Start page 165
End page 175
Total pages 11
Place of publication Bristol, England
Publisher Society for Endocrinology
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous preterm deliveries with intrauterine infection. SOCS1, –2 and –3 mRNAs and proteins were detectable by RT-PCR and immunoblotting respectively, in preterm amnion, choriodecidua and placenta, irrespective of infection status. Immunoperoxidase staining localized SOCS1, –2 and –3 to all cell types of the gestational membranes, with infiltrating leukocytes reacting strongly in infected tissues. In villous placenta, SOCS was immunolocalized to the syncytiotrophoblast with marked staining of round mesenchymal cells, possibly Hofbauer cells. Nuclear SOCS staining was seen in amnion, chorion and placental syncytiotrophoblasts. SOCS proteins were, in general, significantly more abundant in placenta compared with amnion or choriodecidua. Placental SOCS1 and interleukin-1ß concentrations were positively correlated (r2=0.47; P<0.05). However, no changes in SOCS levels in any tissues were observed with intrauterine infection. The relatively large amounts of SOCS proteins in the placenta may reflect a placenta-specific immunoprotective response to minimize the elaboration and effects of cytokines with potential to harm the placenta and fetus. Lack of labor-associated changes in SOCS levels suggests that the regulation of SOCS expression in preterm gestational tissues differs from those at term, perhaps reflecting roles in regulating placental somatotropic responses.
Keyword Socs Proteins
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 12:46:47 EST