Actions of interleukin-4 on prostaglandin biosynthesis at the chorion-decidual interface

Adamson, S., Edwin, S.S., LaMarche, S. and Mitchell, M.D. (1993) Actions of interleukin-4 on prostaglandin biosynthesis at the chorion-decidual interface. American Journal of Obstetrics and Gynecology, 169 6: 1442-1447.

Author Adamson, S.
Edwin, S.S.
LaMarche, S.
Mitchell, M.D.
Title Actions of interleukin-4 on prostaglandin biosynthesis at the chorion-decidual interface
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 1993-12
Sub-type Article (original research)
Volume 169
Issue 6
Start page 1442
End page 1447
Total pages 6
Place of publication St. Louis, Mo. U.S.A.
Publisher Mosby
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objective:
We determined the effects of interleukin-4 on chorion and decidual prostaglandin production.

Study design:

horion and decidual cells from term placentas were grown to confluence. Cells were then incubated with interleukin-4 either alone or with other known stimulants of prostaglandin production: interleukin-1β, epidermal growth factor, ionomycin, or phorbol 12-myristate 13-acetate. Prostaglandin E2 production was determined with a specific radioimmunoassay.

Results:
Interleukin-4 alone stimulated prostaglandin E2 production in chorion and decidual cells. Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1β on prostaglandin E2 production.

Conclusion:
Interleukin-4 stimulates prostaglandin E2 production by chorion and decidual cells. These data suggest that interleukin-4 production by immune effector cells in gestational tissues may contribute to the pathophysiologic features of preterm labor.
Keyword Interleukin-4
Prostaglandins
Cytokines
PRETERM LABOR
Epidermal Growth-factor
Factor-alpha
Cells
Parturition
Activation
Infection
Calcium
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:45:13 EST