G protein-coupled receptor 30 in tumor development

Wang, Dengfeng, Hu, Lina, Zhang, Guonan, Zhang, Lin and Chen, Chen (2010) G protein-coupled receptor 30 in tumor development. Endocrine, 38 1: 29-37. doi:10.1007/s12020-010-9363-z

Author Wang, Dengfeng
Hu, Lina
Zhang, Guonan
Zhang, Lin
Chen, Chen
Title G protein-coupled receptor 30 in tumor development
Journal name Endocrine   Check publisher's open access policy
ISSN 1355-008X
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1007/s12020-010-9363-z
Volume 38
Issue 1
Start page 29
End page 37
Total pages 9
Editor P Michael Conn
Place of publication Totawa, N J, United States
Publisher Humana Press
Collection year 2011
Language eng
Subject C1
920106 Endocrine Organs and Diseases (excl. Diabetes)
060110 Receptors and Membrane Biology
1103 Clinical Sciences
Abstract Estrogen plays several important physiological and pathological functions in not only reproductive system but many other systems as well. Its transcriptional activation has been traditionally described as being mediated by classic nuclear estrogen receptors (ERs). It is however established recently that a novel functional estrogen transmembrane receptor, G protein-coupled receptor 30 (GPR30), modulates both rapid non-genomic events and genomic transcriptional events of estrogen. It has been demonstrated that GPR30 promotes the progress of estrogen-related tumors through mitogen-activated protein kinase (MAPK) signaling pathways. Effects mediated by GPR30 are maintained when classic ERs are absent or blocked. In addition, GPR30 is involved in drug resistance, which is often occurring during cancer treatments. All these new findings strongly imply that GPR30 may be an important therapeutic target for estrogen-related tumors. Simultaneously blocking both GPR30 and classic ERs may be a better strategy for the treatment of estrogen-related tumors. © 2010 Springer Science+Business Media, LLC.
Keyword GPR30
Estrogen receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Review heading

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 22 Aug 2010, 00:09:21 EST