Genetics of allergic disease

HollowayJohn W., Yang, Ian A. and Holgate, Stephen T. (2010) Genetics of allergic disease. Journal of Allergy and Clinical Immunology, 125 2, Supp. 2: S81-S94. doi:10.1016/j.jaci.2009.10.071

Author HollowayJohn W.
Yang, Ian A.
Holgate, Stephen T.
Title Genetics of allergic disease
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1016/j.jaci.2009.10.071
Volume 125
Issue 2, Supp. 2
Start page S81
End page S94
Total pages 14
Place of publication Philadelphia, PA, United States
Publisher Mosby
Collection year 2011
Language eng
Formatted abstract
Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic and interacting environmental factors on their pathophysiology. Recent years have seen considerable progress in unraveling the contribution of these factors to an individual subject's susceptibility to, subsequent development of, and severity of disease. This has resulted in increasing insight into novel areas of allergic disease pathophysiology, for example the significant role played by locally acting tissue susceptibility factors like epithelial/epidermal barrier function and remodeling, such as filaggrin, ADAM33, and GSDML/ORMDL3, in patients with atopic dermatitis and asthma. Furthermore, studies of gene-environment interactions and Mendelian randomization approaches have led to increased insight into the importance of environmental triggers for allergic disease. Studies of the timing of action of genetic variants in determining disease susceptibility have highlighted the importance of in utero development and early life in determining susceptibility to allergic disease. In the future, genetic discoveries in allergic disease will potentially lead to better endophenotyping, prognostication, prediction of treatment response, and insights into molecular pathways to develop more targeted therapy for these conditions. © 2010 American Academy of Allergy, Asthma & Immunology.
Keyword Heritability
Genetic testing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 15 Aug 2010, 00:04:16 EST