Complement expression in mice throughout neural tube closure

Coulthard, L. G. J., Costantini, K. J., Lor, Mary, Simmons, D., Taylor, S. M. and Woodruff, T. M. (2010). Complement expression in mice throughout neural tube closure. In: Berhane Ghebrehiwet, Ellinor I. Peerschke and Richard R. Kew, Molecular Immunology. Proceedings of: XXIII International Complement Workshop. XXIII International Complement Workshop, New York, NY, U.S.A., (2251-2251). 1-5 August 2010. doi:10.1016/j.molimm.2010.05.163

Author Coulthard, L. G. J.
Costantini, K. J.
Lor, Mary
Simmons, D.
Taylor, S. M.
Woodruff, T. M.
Title of paper Complement expression in mice throughout neural tube closure
Conference name XXIII International Complement Workshop
Conference location New York, NY, U.S.A.
Conference dates 1-5 August 2010
Proceedings title Molecular Immunology. Proceedings of: XXIII International Complement Workshop   Check publisher's open access policy
Journal name Molecular Immunology   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Pergamon Press
Publication Year 2010
Year available 2011
Sub-type Poster
DOI 10.1016/j.molimm.2010.05.163
ISSN 0161-5890
Editor Berhane Ghebrehiwet
Ellinor I. Peerschke
Richard R. Kew
Volume 47
Issue 13
Start page 2251
End page 2251
Total pages 1
Language eng
Formatted Abstract/Summary
A role for the complement cascade in mammalian neural development is becoming apparent. There is evidence that complement factors 3a (C3a) and 5a (C5a), are regulators of neural differentiation and proliferation. Our lab has also demonstrated a very high incidence of neural tube defects in mice lacking C5a receptor (C5aR) signaling under maternal folate-deficient conditions.

We are currently investigating specific complement factor and receptor knockout mice in our folate-deficiency model to elucidate their particular functional roles. These results support the hypothesis of a novel role for C3a and C5a in foetal development, with selective localisation to neural proliferative zones, and, in particular, a crucial developmental role following dietary folate deficiency.
Subjects 1107 Immunology
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Presented during the poster session "New and Emerging Topics" on Board #1 as Abstract #238.

Document type: Conference Paper
Collections: Non HERDC
School of Biomedical Sciences Publications
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Created: Sun, 15 Aug 2010, 00:02:03 EST