ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology

Roberts-Thomson, Sarah J., Peters, Amelia A., Grice, Desma M. and Monteith, Gregory R. (2010) ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology. Pharmacology and Therapeutics, 127 2: 121-130. doi:10.1016/j.pharmthera.2010.04.016

Author Roberts-Thomson, Sarah J.
Peters, Amelia A.
Grice, Desma M.
Monteith, Gregory R.
Title ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology
Journal name Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0163-7258
Publication date 2010-08
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pharmthera.2010.04.016
Volume 127
Issue 2
Start page 121
End page 130
Total pages 10
Editor S.J. Enna
J.R. Fozard
L. LeCount
Place of publication Philadelphia PA, U.S.A.
Publisher Elsevier
Collection year 2011
Language eng
Subject C1
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
920102 Cancer and Related Disorders
Formatted abstract
ORAI1 is a protein located on the plasma membrane that acts as a calcium channel. Calcium enters via ORAI1 as a mechanism to refill the sarcoplasmic/endoplasmic reticulum calcium stores, the depletion of which can be detected by the sensor protein STIM1. Isoforms of these proteins ORAI2, ORAI3 and STIM2 also have roles in cellular calcium homeostasis but are less well characterized. This pathway of filling the calcium stores is termed store-operated calcium entry and while the pathway itself was proposed in 1986, the identity of the key molecular components was only discovered in 2005 and 2006. The characterization of the ORAI and STIM proteins has provided clearer information on some calcium-regulated pathways that are important in processes from gene transcription to immune cell function. Recent studies have also suggested the importance of the components of ORAI-mediated calcium entry in some diseases or processes significant in disease including the migration of breast cancer cells and thrombus formation. This review will provide a brief overview of ORAI-mediated calcium entry, its role in physiological and pathophysiological processes, as well as current and potential pharmacological modulators of the components of this important cellular calcium entry pathway.
© 2010 Elsevier Inc.
Keyword Calcium
Store-operated calcium entry
Calcium release activated current
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 15 Aug 2010, 00:01:22 EST