A virulent Wolbachia infection decreases the viability of the dengue vector Aedes aegypti during periods of embryonic quiescence

McMeniman, Connor J. and O'Neill, Scott L. (2010) A virulent Wolbachia infection decreases the viability of the dengue vector Aedes aegypti during periods of embryonic quiescence. Plos Neglected Tropical Diseases, 4 7: . doi:10.1371/journal.pntd.0000748


Author McMeniman, Connor J.
O'Neill, Scott L.
Title A virulent Wolbachia infection decreases the viability of the dengue vector Aedes aegypti during periods of embryonic quiescence
Formatted title
A virulent Wolbachia infection decreases the viability of the dengue vector Aedes aegypti during periods of embryonic quiescence
Journal name Plos Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2727
1935-2735
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1371/journal.pntd.0000748
Open Access Status DOI
Volume 4
Issue 7
Total pages 6
Editor Peter Hotez
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2011
Language eng
Subject 920404 Disease Distribution and Transmission (incl. Surveillance and Response)
060501 Bacteriology
Formatted abstract
A new approach for dengue control has been proposed that relies on life-shortening strains of the obligate intracellular bacterium Wolbachia pipientis to modify mosquito population age structure and reduce pathogen transmission. Previously we reported the stable transinfection of the major dengue vector Aedes aegypti with a life-shortening Wolbachia strain (wMelPop-CLA) from the vinegar fly Drosophila melanogaster. Here, we report a further characterization of the phenotypic effects of this virulent Wolbachia infection on several life-history traits of Ae. aegypti. Minor costs of wMelPop-CLA infection for pre-imaginal survivorship, development and adult size were found. However, we discovered that the wMelPop-CLA infection dramatically decreased the viability of desiccated Ae. aegypti eggs over time. Similarly, the reproductive fitness of wMelPop-CLA infected Ae. aegypti females declined with age. These results reveal a general pattern associated with wMelPop-CLA induced pathogenesis in this mosquito species, where host fitness costs increase during aging of both immature and adult life-history stages. In addition to influencing the invasion dynamics of this particular Wolbachia strain, we suggest that the negative impact of wMelPop-CLA on embryonic quiescence may have applied utility as a tool to reduce mosquito population size in regions with pronounced dry seasons or in regions that experience cool winters.
© 2010 McMeniman, O'Neill.

Keyword Blood feeding success
Host
Albopictus
Mosquito
Age
Populations
Drosophila
Culicidae
Symbiont
Diptera
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 15 Aug 2010, 00:01:11 EST