Reduced intensity conditioning for hematopoietic stem cell transplantation: Has it achieved all it set out to?

Turner, Brie E., Collin, Matthew and Rice, Alison M. (2010) Reduced intensity conditioning for hematopoietic stem cell transplantation: Has it achieved all it set out to?. Cytotherapy, 12 4: 440-454. doi:10.3109/14653241003709678


Author Turner, Brie E.
Collin, Matthew
Rice, Alison M.
Title Reduced intensity conditioning for hematopoietic stem cell transplantation: Has it achieved all it set out to?
Journal name Cytotherapy   Check publisher's open access policy
ISSN 1465-3249
1477-2566
Publication date 2010-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/14653241003709678
Volume 12
Issue 4
Start page 440
End page 454
Total pages 15
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2011
Language eng
Abstract At its inception, reduced intensity conditioning (RIC) was heralded as a means to limit toxicity after hematopoietic stem cell transplantation (HSCT), especially for the older patient demographic. The aim was to promote the inherent anti-leukemic activity of the transplant whilst reducing toxicity and transplant-related mortality (TRM). More than 10 years on, much has been learnt about the role of conditioning in determining outcomes after transplantation. The use of RIC as a preparative regimen has increased the number of patients that can benefit from HSCT because the initial therapy is less toxic. However, many of the early pioneers of RIC quickly realized that the toxicity from graft-versus-host disease (GvHD) was equally as potent as that from conditioning. Furthermore, questions remain concerning the efficacy of RIC regimens in retaining anti-leukemic immunity, especially in cases of aggressive disease. The undoubted synergy between chemotherapeutic and immunologic treatment of malignancy means that reduction of conditioning intensity to minimal levels may not be entirely logical. © 2010 Informa UK Ltd.
Keyword Delayed-onset graft-versus-host disease
Hematopoietic stem cell transplantation
Myeloablative conditioning
Patient outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 08 Aug 2010, 00:06:26 EST