Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses

Nasreen, Mariam, Waldie, Tanya M., Dixon, Chantelle M. and Steptoe, Raymond J. (2010) Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses. European Journal of Immunology, 40 7: 2016-2025. doi:10.1002/eji.200940085


Author Nasreen, Mariam
Waldie, Tanya M.
Dixon, Chantelle M.
Steptoe, Raymond J.
Title Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses
Formatted title
Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses
Journal name European Journal of Immunology   Check publisher's open access policy
ISSN 0014-2980
1521-4141
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1002/eji.200940085
Volume 40
Issue 7
Start page 2016
End page 2025
Total pages 10
Editor Foo Yoo Liew
Place of publication Weinheim, Germany
Publisher Wiley-VCH
Collection year 2011
Language eng
Formatted abstract
CD4+ T cells are important effectors of inflammation and tissue destruction in many diseases of immune dysregulation. As memory T cells develop early during the preclinical stages of autoimmune and inflammatory diseases, immunotherapeutic approaches to treatment of these diseases, once established, must include the means to terminate memory T-cell responses. Traditionally, it has been considered that, due to their terminally differentiated nature, memory T cells are resistant to tolerance induction, although emerging evidence indicates that some immunotherapeutic approaches can terminate memory T-cell responses. Here, we demonstrate that CD4+ memory T-cell responses can be terminated when cognate antigen is transgenically expressed in steady-state DC. Transfer of in-vitro-generated CD4+ memory T cells establishes, in nontransgenic recipients, a stable and readily recalled memory response to cognate antigen. In contrast, upon transfer to mice expressing cognate antigen targeted to DC, memory CD4+ T cells undergo a phase of limited proliferation followed by substantial deletion, and recall responses are effectively silenced. This finding is important in understanding how to effectively apply immunotherapy to ongoing T-cell-mediated autoimmune and inflammatory diseases.
Keyword CD4(+) T cells
DC
Tolerance
Parenchymal self-antigen
In-vivo
Peripheral tolerance
Cross-presentation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 08 Aug 2010, 00:06:14 EST