Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia

Fernandez, Liza S., Sykes, Melissa L., Andrews, Katherine T. and Avery, Vicky M. (2010) Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia. International Journal of Antimicrobial Agents, 36 3: 275-279. doi:10.1016/j.ijantimicag.2010.05.008


Author Fernandez, Liza S.
Sykes, Melissa L.
Andrews, Katherine T.
Avery, Vicky M.
Title Antiparasitic activity of alkaloids from plant species of Papua New Guinea and Australia
Journal name International Journal of Antimicrobial Agents   Check publisher's open access policy
ISSN 0924-8579
1872-7913
Publication date 2010-09-01
Sub-type Article (original research)
DOI 10.1016/j.ijantimicag.2010.05.008
Volume 36
Issue 3
Start page 275
End page 279
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2011
Language eng
Formatted abstract
New drugs are needed to help overcome the increasing problem of drug resistance in parasites that cause diseases such as malaria and trypanosomiasis. In this study, alkaloid compounds isolated from extracts of the plants Flindersia amboinensis, Stephania zippeliana and Voacanga papuana from Papua New Guinea and Flindersia acuminata from Australia were examined for their antiparasitic activity against Plasmodium falciparum strains and Trypanosoma brucei brucei as well as their cytotoxicity against the mammalian cell lines HEK 293 and HeLa. The most active compound, dimethylisoborreverine (DMIB), showed submicromolar activity, with 50% inhibitory concentration (IC50) values between 20nM and 810nM both against drug-sensitive and drug-resistant P. falciparum strains, along with moderate selectivity against T. b. brucei and mammalian cells. Stage specificity studies revealed that P. falciparum trophozoite-stage parasites were more susceptible to DMIB than ring- or schizont-stage parasites. DMIB-treated trophozoites showed changes in food vacuole morphology, with an apparent reduction in haemozoin formation that does not appear to be inhibited via the direct binding of haem. These findings suggest a potential for indole alkaloids from Flindersia spp. as new antiparasitic agents. © 2010 Elsevier B.V. and the International Society of Chemotherapy.
Keyword Antimalarial
Antitrypanosomal
Alkaloid
Plant
Flindersia
Stage specificity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Sun, 08 Aug 2010, 10:05:07 EST