Using serological measures to monitor changes in malaria transmission in Vanuatu

Cook, J, Reid, H, Iavro, J, Kuwahata, M, Taleo, G, Clements, A, McCarthy, J, Vallely, A and Drakeley, C (2010) Using serological measures to monitor changes in malaria transmission in Vanuatu. Malaria Journal, 9 1: 169-1-169-15. doi:10.1186/1475-2875-9-169


Author Cook, J
Reid, H
Iavro, J
Kuwahata, M
Taleo, G
Clements, A
McCarthy, J
Vallely, A
Drakeley, C
Title Using serological measures to monitor changes in malaria transmission in Vanuatu
Journal name Malaria Journal   Check publisher's open access policy
ISSN 1475-2875
Publication date 2010-06
Sub-type Article (original research)
DOI 10.1186/1475-2875-9-169
Open Access Status DOI
Volume 9
Issue 1
Start page 169-1
End page 169-15
Total pages 15
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Collection year 2011
Language eng
Formatted abstract
Background: With renewed interest in malaria elimination, island environments present unique opportunities to
achieve this goal. However, as transmission decreases, monitoring and evaluation programmes need increasingly
sensitive tools to assess Plasmodium falciparum and Plasmodium vivax exposure. In 2009, to assess the role of
serological markers in evaluating malaria transmission, a cross-sectional seroprevalence study was carried out in Tanna
and Aneityum, two of the southernmost islands of the Vanuatu archipelago, areas where malaria transmission has been
variably reduced over the past few decades.
Methods: Malaria transmission was assessed using serological markers for exposure to P. falciparum and P. vivax. Filter
blood spot papers were collected from 1,249 people from Tanna, and 517 people from Aneityum to assess the
prevalence of antibodies to two P. falciparum antigens (MSP-119 and AMA-1) and two P. vivax antigens (MSP-119 and
AMA-1). Age-specific prevalence was modelled using a simple catalytic conversion model based on maximum
likelihood to generate a community seroconversion rate (SCR).
Results: Overall seropositivity in Tanna was 9.4%, 12.4% and 16.6% to P. falciparum MSP-119, AMA-1 and Schizont
Extract respectively and 12.6% and 15.0% to P. vivax MSP-119 and AMA-1 respectively. Serological results distinguished
between areas of differential dominance of either P. vivax or P. falciparum and analysis of age-stratified results showed a
step in seroprevalence occurring approximately 30 years ago on both islands, indicative of a change in transmission
intensity at this time. Results from Aneityum suggest that several children may have been exposed to malaria since the
2002 P. vivax epidemic.
Conclusion: Seroepidemiology can provide key information on malaria transmission for control programmes, when
parasite rates are low. As Vanuatu moves closer to malaria elimination, monitoring changes in transmission intensity
and identification of residual malaria foci is paramount in order to concentrate intervention efforts. © 2010 Cook et al; licensee BioMed Central Ltd.
Keyword Entomological inoculation rate
Falciparum merozoite antigens
Apical membrane antigen-1
West-African savanna
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article# 169, pp.1-15

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
School of Medicine Publications
 
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Created: Sun, 08 Aug 2010, 00:02:52 EST