The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production

Potter, A. J., Kidd, S. P., McEwan, A. G. and Paton, J. C. (2010) The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production. Journal of Bacteriology, 192 15: 4063-4066. doi:10.1128/JB.00383-10

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Author Potter, A. J.
Kidd, S. P.
McEwan, A. G.
Paton, J. C.
Title The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production
Formatted title
The MerR/NmlR family transcription factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production
Journal name Journal of Bacteriology   Check publisher's open access policy
ISSN 0021-9193
1067-8832
1098-5530
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1128/JB.00383-10
Open Access Status File (Publisher version)
Volume 192
Issue 15
Start page 4063
End page 4066
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2011
Language eng
Formatted abstract
The NmlRsp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlRsp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlRsp strain exhibits increased resistance to high oxygen tension, attributable to decreased H2O2 production, which correlated with downregulation of carbamoyl phosphate synthase (carB). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlRsp in the regulation of carbon metabolism. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Keyword Growth
Pyruvate oxidase
Virulence
Disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 01 Aug 2010, 00:05:14 EST