Leukemia stem cells

Lane, Steven W. and Gilliland, D. Gary (2010) Leukemia stem cells. Seminars in Cancer Biology, 20 2: 71-76. doi:10.1016/j.semcancer.2009.12.001


Author Lane, Steven W.
Gilliland, D. Gary
Title Leukemia stem cells
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1044-579X
Publication date 2010-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcancer.2009.12.001
Volume 20
Issue 2
Start page 71
End page 76
Total pages 6
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2011
Language eng
Abstract Leukemia stem cells (LSC) reside within a hierarchy of malignant hematopoiesis and possess the ability to instigate, maintain and serially propagate leukemia in vivo, while retaining the capacity to differentiate into committed progeny that lack these properties. In most cases, LSC appear to share immunophenotypic characteristics with committed hematopoietic progenitors, however have pathologically enhanced self-renewal, mediated through the activation of certain cellular pathways. The presence of a LSC that solely possesses the ability to initiate and sustain leukemia has implications for the treatment of patients with this disease. In this review, we will discuss these issues as well as some of the recent controversies regarding LSC frequency and alternative theories of leukemogenesis. © 2009 Published by Elsevier Ltd.
Formatted abstract
Leukemia stem cells (LSC) reside within a hierarchy of malignant hematopoiesis and possess the ability to instigate, maintain and serially propagate leukemia in vivo, while retaining the capacity to differentiate into committed progeny that lack these properties. In most cases, LSC appear to share immunophenotypic characteristics with committed hematopoietic progenitors, however have pathologically enhanced self-renewal, mediated through the activation of certain cellular pathways. The presence of a LSC that solely possesses the ability to initiate and sustain leukemia has implications for the treatment of patients with this disease. In this review, we will discuss these issues as well as some of the recent controversies regarding LSC frequency and alternative theories of leukemogenesis. © 2009 Published by Elsevier Ltd.
Keyword Leukemia
Leukemia stem cells
Cancer stem cells
Acute Myeloid-leukemia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 01 Aug 2010, 10:00:33 EST