Modified polyunsaturated fatty acids

Ferrante, Antonio, Poulos, Alfred, Easton, Christopher John, Pitt, Michael Joseph, Robertson, Thomas Alistair and Rathjen, Deborah Ann (1996). Modified polyunsaturated fatty acids. WO/1996/011908.

Creator Ferrante, Antonio
Poulos, Alfred
Easton, Christopher John
Pitt, Michael Joseph
Robertson, Thomas Alistair
Rathjen, Deborah Ann
Patent title Modified polyunsaturated fatty acids
Date of issue 1996-04-25
Patent owner Peptide Technology Limited; Women's and Children's Hospital Adelaide; Antonio Ferrante, Alfred Poulos; Christopher John Easton; Michael Joseph Pitt; Thomas Alistair Robertson; Deborah Ann Rathjen
Patent number WO/1996/011908
Country of origin Australia
Language eng
Subjects 110104 Medical Biochemistry: Lipids
030503 Organic Chemical Synthesis
Abstract/Summary The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two substitutions selected from the group consisting of $g(b) oxa, $g(g) oxa, $g(b) thia and $g(g) thia. It is also preferred that the polyunsaturated fatty acid compound includes a further substitution selected from the group consisting of hydroxy, hydroperoxy, peroxy, carboxymethyl substitutions or attached to an amino acid. The invention also provides a method of producing an unsaturated oxa substituted fatty acid comprising reacting an unsaturated fatty acid alcohol with a carbene that is inserted in the OH bond of the alcohol. The invention further provides a method of treating inflammation with a composition comprising at least one hydroxy, hydroperoxy or peroxy derivative of a polyunsaturated fatty acid having a C¿18-24? carbon chain and 1-6 cis or trans double bonds.
Additional Notes Publication Date: 25 April 1996. International Filing Date: 13 October 1995. International Application No.: PCT/AU1995/000677.

Document type: Patent
Collection: School of Medicine Publications
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Created: Wed, 28 Jul 2010, 15:39:57 EST by Mary-Anne Marrington on behalf of The University of Queensland Library