Binding of copper(II) to the cyclic octapeptide patellamide D

Van den Brenk, Anna L., Fairlie, David P., Hanson, Graeme R., Gahan, Lawrence R., Hawkins, Clifford J. and Jones, Alun (1994) Binding of copper(II) to the cyclic octapeptide patellamide D. Inorganic Chemistry, 33 10: 2280-2289. doi:10.1021/ic00088a034


Author Van den Brenk, Anna L.
Fairlie, David P.
Hanson, Graeme R.
Gahan, Lawrence R.
Hawkins, Clifford J.
Jones, Alun
Title Binding of copper(II) to the cyclic octapeptide patellamide D
Journal name Inorganic Chemistry   Check publisher's open access policy
ISSN 0020-1669
Publication date 1994-05
Sub-type Article (original research)
DOI 10.1021/ic00088a034
Volume 33
Issue 10
Start page 2280
End page 2289
Total pages 9
Place of publication Easton, PA. U.S.A.
Publisher American Chemical Society
Language eng
Subject 030201 Bioinorganic Chemistry
Formatted abstract
Patellamide D (patH4), a cyclic octapeptide from the ascidian Lissoclinum patella, with two oxazoline and two thiazole rings, has the 24-azacrown-8 macrocyclic structure. The cyclic octapeptide forms multiple mononuclear copper(II) complexes in which there are three nitrogen ligating atoms, arising from a deprotonated amide and oxazoline and thiazole rings, coordinated to the copper(II) ion. The multiple mononuclear copper(II) complexes can be ascribed to different metal binding sites in patH4; there are four in the asymmetric patH4 molecule and the binding of different ligands (Ch or H2O) to the fourth equatorial coordination site. Patellamide D also forms three binuclear copper(II) complexes ([Cu2(patH2)]2+, [Cu2(PatH2)(OH)]+, and [Cu2(patH2)(CO3)]) in which each copper(II) ion is coordinated by three nitrogen ligating atoms from a deprotonated amide and oxazoline and thiazole rings. The remaining coordination sites may be occupied by either Cl- or H2O in the first two complexes, while carbonate is assumed, on the basis of X-ray crystallography presented in a future paper, to bridge the two copper(II) ions in the third complex. Electronic absorption, circular dichroism, electron paramagnetic resonance, and mass spectra are reported as a function of the concentration of base added to the copper(II) patellamide solutions. © 1994 American Chemical Society.
Keyword Electron-paramagnetic-res
Metal-ion complexes
Lissoclinum-patella
Ascidiacyclamide
Peptides
Spectroscopy
Crystal
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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