Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain

Bradford, D., Faull, R. L. M., Curtis, M. A. and Cooper, H. M. (2010) Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain. Journal of Comparative Neurology, 518 16: 3237-3253. doi:10.1002/cne.22397


Author Bradford, D.
Faull, R. L. M.
Curtis, M. A.
Cooper, H. M.
Title Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
1096-9861
Publication date 2010-08-15
Sub-type Article (original research)
DOI 10.1002/cne.22397
Volume 518
Issue 16
Start page 3237
End page 3253
Total pages 17
Place of publication Hoboken, U.S.A.
Publisher John Wiley and Sons
Collection year 2011
Language eng
Abstract In the adult rodent forebrain, astrocyte-like neural stem cells reside within the subventricular zone (SVZ) and give rise to progenitors and neuroblasts, which then undergo chain migration along the rostral migratory stream (RMS) to the olfactory bulb, where they mature into fully functional interneurons. Neurogenesis also occurs in the adult human SVZ, where neural precursors similar to the rodent astrocyte-like stem cell and neuroblast have been identified. A migratory pathway equivalent to the rodent RMS has also recently been described for the human forebrain. In the embryo, the guidance receptor neogenin and its ligands netrin-1 and RGMa regulate important neurogenic processes, including differentiation and migration. We show in this study that neogenin is expressed on neural stem cells (B cells), progenitor cells (C cells), and neuroblasts (A cells) in the adult mouse SVZ and RMS. We also show that netrin-1 and RGMa are ideally placed within the neurogenic niche to activate neogenin function. Moreover, we find that neogenin and RGMa are also present in the neurogenic regions of the human adult forebrain. We show that neogenin is localized to cells displaying stem cell (B cell)-like characteristics within the adult human SVZ and RMS and that RGMa is expressed by the same or a closely apposed cell population. This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain.
© 2010 Wiley-Liss, Inc.
Keyword Neural stem cell
Neural migration
Subventricular zone
Rostral migratory stream
Adult neurogenesis
Repulsive guidance molecule
Rostral migratory stream
Neural stem-cells
Central-nervous-system
Expression patterns
Subventricular zone
Multiple roles
Axon guidance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 25 Jul 2010, 00:05:31 EST