Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle

Kirkness, EF, Haas, BJ, Sun, WL, Braig, HR, Perotti, MA, Clark, JM, Lee, SH, Robertson, HM, Kennedy, RC, Elhaik, E, Gerlach, D, Kriventseva, EV, Elsik, CG, Graur, D, Hill, CA, Veenstra, JA, Walenz, B, Tubio, JMC, Ribeiro, JMC, Rozas, J, Johnston, JS, Reese, JT, Popadic, A, Tojo, M, Raoult, D, Reed, DL, Tomoyasu, Y, Krause, E, Mittapalli, O, Margam, VM, Li, HM, Meyer, JM, Johnson, RM, Romero-Severson, J, VanZee, JP, Alvarez-Ponce, D, Vieira, FG, Aguade, M, Guirao-Rico, S, Anzola, JM, Yoon, KS, Strycharz, JP, Unger, MF, Christley, S, Lobo, NF, Seufferheld, MJ, Wang, NK, Dasch, GA, Struchiner, CJ, Madey, G, Hannick, LI, Bidwell, S, Joardar, V, Caler, E, Shao, RF, Barker, SC, Cameron, S, Bruggner, RV, Regier, A, Johnson, J, Viswanathan, L, Utterback, TR, Sutton, GG, Lawson, D, Waterhouse, RM, Venter, JC, Strausberg, RL, Berenbaum, MR, Collins, FH, Zdobnov, EM and Pittendrigh, BR (2010) Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. Proceedings of the National Academy of Sciences of the United States of America, 107 27: 12168-12173. doi:10.1073/pnas.1003379107


Author Kirkness, EF
Haas, BJ
Sun, WL
Braig, HR
Perotti, MA
Clark, JM
Lee, SH
Robertson, HM
Kennedy, RC
Elhaik, E
Gerlach, D
Kriventseva, EV
Elsik, CG
Graur, D
Hill, CA
Veenstra, JA
Walenz, B
Tubio, JMC
Ribeiro, JMC
Rozas, J
Johnston, JS
Reese, JT
Popadic, A
Tojo, M
Raoult, D
Reed, DL
Tomoyasu, Y
Krause, E
Mittapalli, O
Margam, VM
Li, HM
Meyer, JM
Johnson, RM
Romero-Severson, J
VanZee, JP
Alvarez-Ponce, D
Vieira, FG
Aguade, M
Guirao-Rico, S
Anzola, JM
Yoon, KS
Strycharz, JP
Unger, MF
Christley, S
Lobo, NF
Seufferheld, MJ
Wang, NK
Dasch, GA
Struchiner, CJ
Madey, G
Hannick, LI
Bidwell, S
Joardar, V
Caler, E
Shao, RF
Barker, SC
Cameron, S
Bruggner, RV
Regier, A
Johnson, J
Viswanathan, L
Utterback, TR
Sutton, GG
Lawson, D
Waterhouse, RM
Venter, JC
Strausberg, RL
Berenbaum, MR
Collins, FH
Zdobnov, EM
Pittendrigh, BR
Title Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2010-07-01
Sub-type Article (original research)
DOI 10.1073/pnas.1003379107
Open Access Status Not Open Access
Volume 107
Issue 27
Start page 12168
End page 12173
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Collection year 2011
Language eng
Formatted abstract
As an obligatory parasite of humans, the body louse (Pediculus humanus humanus) is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. Here, we present genome sequences of the body louse and its primary bacterial endosymbiont Candidatus Riesia pediculicola. The body louse has the smallest known insect genome, spanning 108 Mb. Despite its status as an obligate parasite, it retains a remarkably complete basal insect repertoire of 10,773 protein-coding genes and 57 microRNAs. Representing hemimetabolous insects, the genome of the body louse thus provides a reference for studies of holometabolous insects. Compared with other insect genomes, the body louse genome contains significantly fewer genes associated with environmental sensing and response, including odorant and gustatory receptors and detoxifying enzymes. The unique architecture of the 18 minicircular mitochondrial chromosomes of the body louse may be linked to the loss of the gene encoding the mitochondrial single-stranded DNA binding protein. The genome of the obligatory louse endosymbiont Candidatus Riesia pediculicola encodes less than 600 genes on a short, linear chromosome and a circular plasmid. The plasmid harbors a unique arrangement of genes required for the synthesis of pantothenate, an essential vitamin deficient in the louse diet. The human body louse, its primary endosymbiont, and the bacterial pathogens that it vectors all possess genomes reduced in size compared with their free-living close relatives. Thus, the body louse genome project offers unique information and tools to use in advancing understanding of coevolution among vectors, symbionts, and pathogens.
Keyword Coevolution
Comparative genomics
Ectoparasite
Drosophila melanogaster
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 25 Jul 2010, 00:02:41 EST