Macrophages in renal development, injury, and repair

Williams, Timothy M., Little, Melissa H. and Ricardo, Sharon D. (2010) Macrophages in renal development, injury, and repair. Seminars in Nephrology, 30 3: 255-267. doi:10.1016/j.semnephrol.2010.03.011

Author Williams, Timothy M.
Little, Melissa H.
Ricardo, Sharon D.
Title Macrophages in renal development, injury, and repair
Journal name Seminars in Nephrology   Check publisher's open access policy
ISSN 0270-9295
Publication date 2010-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semnephrol.2010.03.011
Volume 30
Issue 3
Start page 255
End page 267
Total pages 13
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Collection year 2011
Language eng
Abstract Macrophages have long been regarded as classic mediators of innate immunity because of their production of proinflammatory cytokines and their ability to induce apoptotic cell death. As a result of such activities and the detrimental long-term effect of kidney inflammation, macrophages principally have been regarded as mediators of glomerular damage, tubular cell death, and the downstream fibrotic events leading to chronic kidney disease. Although this has been the accepted consequence of macrophage infiltration in kidney disease, macrophages also play a critical role in normal organ development, cell turnover, and recovery from injury in many organs, including the kidney. There is also a growing awareness that there is considerable heterogeneity of phenotype and function within the macrophage population and that a greater understanding of these different states of activation may result in the development of therapies specifically designed to capitalize on this variation in phenotype and cellular responses. In this review, we discuss the current understanding of induction and consequences of classic versus alternative macrophage activation and highlight what additional therapeutic options this may provide for the management of both acute and chronic kidney disease as well as renal cancer. Copyright © 2010 Elsevier Inc. All rights reserved.
Keyword Macrophage
Kidney Development
Innate immunity
Classic activation
Alternative activation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 25 Jul 2010, 00:02:19 EST