The synthesis and characterization of lipophilic peptide-based carriers for gene delivery

Coles, DJ, Esposito, A, Chuah, HT and Toth, I (2010) The synthesis and characterization of lipophilic peptide-based carriers for gene delivery. Tetrahedron, 66 29: 5435-5441. doi:10.1016/j.tet.2010.05.031


Author Coles, DJ
Esposito, A
Chuah, HT
Toth, I
Title The synthesis and characterization of lipophilic peptide-based carriers for gene delivery
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
1464-5416
Publication date 2010-07-17
Sub-type Article (original research)
DOI 10.1016/j.tet.2010.05.031
Volume 66
Issue 29
Start page 5435
End page 5441
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Abstract Lipophilic carriers have shown great potential in improving the delivery of gene therapeutics.We have synthesized positively charged peptide-based carriers including lipoamino acids.The carriers were shown to interact with DNA by performing isothermal titration calorimetry and particle size and zeta potential experiments.An exothermic reaction resulted from the titration of carrier into DNA.The particle sizes of the carrier/DNA complexes varied over the different charge ratios from 200-800 nm.The zeta potential was negative at a low charge ratio but positive when the amount of carrier was increased.The utilisation of lipophilic carriers is a promising approach to improve the bioavailability of gene delivery. © 2010 Elsevier Ltd.All rights reserved.
Keyword Gene delivery
Lipid carriers
Isothermal titration calorimetry
Zetasizer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
 
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Created: Sun, 25 Jul 2010, 10:02:11 EST