EPR Characterisation of the Cr(V) Intermediates in the Cr(VI/V) Oxidations of Organic Substrates and of Relevance to Cr-Induced Cancers

Barr-David, Gregory, Charara, Mary, Codd, Rachel, Farrell, Rodney P., Irwin, Jennifer A., Lay, Peter A., Bramley, Richard, Brumby, Steven, Ji, Ji-Ying and Hanson, Graeme R. (1995) EPR Characterisation of the Cr(V) Intermediates in the Cr(VI/V) Oxidations of Organic Substrates and of Relevance to Cr-Induced Cancers. Journal of the Chemical Society, Faraday Transactions, 91 8: 1207-1216.


Author Barr-David, Gregory
Charara, Mary
Codd, Rachel
Farrell, Rodney P.
Irwin, Jennifer A.
Lay, Peter A.
Bramley, Richard
Brumby, Steven
Ji, Ji-Ying
Hanson, Graeme R.
Title EPR Characterisation of the Cr(V) Intermediates in the Cr(VI/V) Oxidations of Organic Substrates and of Relevance to Cr-Induced Cancers
Journal name Journal of the Chemical Society, Faraday Transactions
Publication date 1995
Sub-type Article
DOI 10.1039/FT9959101207
Volume number 91
Issue number 8
ISSN 0956-5000: 1364-5455
Start page 1207
End page 1216
Total pages 10
Place of publication Cambridge, England
Publisher Royal Society of Chemistry
Language eng
Subject 030201 Bioinorganic Chemistry
Formatted abstract An empirical method has been developed for determining the coordination number of CrV complexes (five- or six-coordinate) and the donor groups bound to CrV from the measured giso and Aiso values. The giso values depend only on the nature of the donor groups and the number of each group, which is very useful in the characterisation of the coordination number and donors. By contrast, the Aiso values appear to be sensitive to the nature of the equatorial donor atoms and the coordination geometry. Strong correlations have been found between the giso values of isoelectronic CrV and VIV complexes and between the Aiso values of analogous complexes of these two metal ions. These, combined, have been used to understand the solution chemistry of CrV using EPR spectroscopy. Such studies have also been invaluable in unravelling the biochemistry that occurs in cell media and cells exposed to carcinogenic CrVI and, hence, possible mechanisms of Cr-induced cancers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article
Collection: Centre for Advanced Imaging Publications
 
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