Characterization of the potent insulin mimetic agent bis(maltolato)oxovanadium(IV) (BMOV) in solution by EPR spectroscopy

Hanson, Graeme R., Sun, Yan and Orvig, Chris (1996) Characterization of the potent insulin mimetic agent bis(maltolato)oxovanadium(IV) (BMOV) in solution by EPR spectroscopy. Inorganic Chemistry, 35 22: 6507-6512. doi:10.1021/ic960490p


Author Hanson, Graeme R.
Sun, Yan
Orvig, Chris
Title Characterization of the potent insulin mimetic agent bis(maltolato)oxovanadium(IV) (BMOV) in solution by EPR spectroscopy
Journal name Inorganic Chemistry   Check publisher's open access policy
ISSN 0020-1669
Publication date 1996-10-23
Sub-type Article (original research)
DOI 10.1021/ic960490p
Volume 35
Issue 22
Start page 6507
End page 6512
Total pages 6
Place of publication Easton, PA. U.S.A.
Publisher American Chemical Society
Language eng
Subject 030201 Bioinorganic Chemistry
Formatted abstract
Bis(maltolato)oxovanadium(IV) (abbreviated BMOV or VO(ma)2) has been characterized by electron paramagnetic resonance (EPR) spectroscopy in CH2Cl2, H2O, MeOH, and pyridine at both room and low temperatures. Spin Hamiltonian parameters for mono- and bis(maltolato)oxovanadium(IV) complexes [VO(ma)]+ (=[VO(ma)(H2O)n+, n -2 or 3) and VO(ma)2 (Hma = 3-hydroxy-2-methyl-4-pyrone, maltol) have been obtained by computer simulation (SOPHE). Configurations of solvated vanadyl/maltol complexes, VO(ma)2S, in solution (S = solvent) are proposed on the basis of a comparison of their hyperfine coupling constants with those obtained for related vanadium(IV) compounds in the literature. Whereas at room temperature pyridine coordinates to VO(ma)2 in a position cis to the oxo ligand (cis isomer), in H2O or in MeOH solvated and unsolvated cis and trans adducts of VO(ma)2 are all formed, with the cis isomer dominant. As expected, the coordinating ability was found to be in the order py > H2O ∼ MeOH > CH2Cl2. In aqueous solutions at room temperature and neutral pH, cis- and trans-VO(ma)2(H2O) complexes are present as major and minor components, respectively.
Keyword Electron-paramagnetic-res
Diabetic rats
Vanadyl complexes
Future treatment
Glucose
Adipocytes
Chemistry
Sulfate
Mimics
Kinase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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