Hepatocellular carcinoma

Macdonald, Graeme A. (1997) Hepatocellular carcinoma. Current Opinion In Gastroenterology, 13 3: 257-262. doi:10.1097/00001574-199705000-00012

Author Macdonald, Graeme A.
Title Hepatocellular carcinoma
Journal name Current Opinion In Gastroenterology   Check publisher's open access policy
ISSN 0267-1379
Publication date 1997
Sub-type Article (original research)
DOI 10.1097/00001574-199705000-00012
Volume 13
Issue 3
Start page 257
End page 262
Total pages 6
Place of publication Philadelphia, PA, USA
Publisher Lippincott, Williams & Wilkins
Collection year 1998
Language eng
Subject 321006 Gastroenterology and Hepatology
1103 Clinical Sciences
Abstract The mechanisms of hepatic carcinogenesis remain a major focus of research. Progress has been made in the identification of genetic changes occurring in premalignant liver, with evidence that dysplastic liver is neoplastic. Significantly, oncogenic changes are also present in cirrhotic liver. With respect to metabolic pathways relevant to hepatocellular carcinoma, there is increasing emphasis on the balance between the proliferative effects of insulinlike growth factors and the antineoplastic effects of transforming growth factor-β. These and other studies are elucidating the histologic, genetic, and related metabolic steps that are relevant to malignant transformation. Clinically, dysplasia present on liver biopsy has been used to identify patients at increased risk of developing hepatocellular carcinoma. This predictive testing has implications for the treatment of patients with compensated cirrhosis. Additionally, there is tantalizing and controversial evidence that treatment of hepatitis C-related cirrhosis with interferon may reduce the risk of hepatocellular carcinoma.
Keyword Gastroenterology & Hepatology
Tumor-suppressor Gene
Receptor Substrate-1 Overexpression
Factor-ii Receptor
Frequent Loss
P53 Gene
Transforming Growth-factor-beta-1
Colorectal Carcinomas
Elevated Levels
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Wed, 21 Jul 2010, 12:05:53 EST by Laura McTaggart on behalf of Faculty Of Health Sciences