A molecular clock based on the expansion of gene families

Trusov, Y. A. and Dear, P. H. (1996) A molecular clock based on the expansion of gene families. Nucleic Acids Research, 24 6: 995-999. doi:10.1093/nar/24.6.995

Author Trusov, Y. A.
Dear, P. H.
Title A molecular clock based on the expansion of gene families
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
Publication date 1996
Sub-type Article (original research)
DOI 10.1093/nar/24.6.995
Open Access Status DOI
Volume 24
Issue 6
Start page 995
End page 999
Total pages 5
Place of publication Oxford, UK
Publisher Oxford University Press
Language eng
Subject 060409 Molecular Evolution
Abstract There is evidence to suggest that eukaryotic genomes are subject to frequent insertions and deletions of non-coding DNA. This may lead to a gradual increase or decrease in genome size, or to a dynamic equilibrium in which the overall size remains constant. We argue, however, that there is a bias favouring an accumulation of non-coding DNA in the proximity of genes. Such bias causes a progressive change in genome structure regardless of whether the overall genome size increases, decreases or remains constant. We show that this change may serve as a 'molecular clock', supplementing that provided by nucleotide substitution rates.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Tue, 20 Jul 2010, 09:02:03 EST by Laura McTaggart on behalf of Faculty of Science