Regulation of vertebrate muscle differentiation by thyroid hormone: the role of the myoD gene family

Muscat, George E. O., Downes, Michael and Dowhan, Dennis H. (1995) Regulation of vertebrate muscle differentiation by thyroid hormone: the role of the myoD gene family. BioEssays, 17 3: 211-218. doi:10.1002/bies.950170307

Author Muscat, George E. O.
Downes, Michael
Dowhan, Dennis H.
Title Regulation of vertebrate muscle differentiation by thyroid hormone: the role of the myoD gene family
Formatted title
Regulation of vertebrate muscle differentiation by thyroid hormone: The role of the myoD gene family
Journal name BioEssays   Check publisher's open access policy
ISSN 1521-1878
Publication date 1995-03
Sub-type Article (original research)
DOI 10.1002/bies.950170307
Volume 17
Issue 3
Start page 211
End page 218
Total pages 8
Place of publication New York, USA
Publisher Wiley
Language eng
Subject 060199 Biochemistry and Cell Biology not elsewhere classified
Formatted abstract
Skeletal myoblasts have their origin early in embryogenesis within specific somites. Determined myoblasts are committed to a myogenic fate; however, they only differentiate and express a muscle-specific phenotype after they have received the appropriate environmental signals. Once proliferating myoblasts enter the differentiation programme they withdraw from the cell cycle and form post-mitotic multinucleated myofibres (myogenesis); this transformation is accompanied by muscle-specific gene expression. Muscle development is associated with complex and diverse protein isoform transitions, generated by differential gene expression and mRNA splicing. The myofibres are in a state of dynamic adaptation in response to hormones, mechanical activity and motor innervation, which modulate differential gene expression and splicing during this functional acclimatisation. This review will focus on the profound effects of thyroid hormone on skeletal muscle, which produce alterations in gene and isoform expression, biochemical properties and morphological features that precipitate in modified contractile/mechanical characteristics. Insight into the molecular events that control these events was provided by the recent characterisation of the MyoD gene family, which encodes helix-loop-helix proteins; these activate muscle-specific transcription and serve as targets for a variety of physiological stimuli. The current hypothesis on hormonal regulation of myogenesis is that thyroid hormones (1) directly regulate the myoD and contractile protein gene families, and (2) induce thyroid hormone receptor-transcription factor interactions critical to gene expression.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 73 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 19 Jul 2010, 12:19:51 EST by Laura McTaggart on behalf of UQ Diamantina Institute