Traumatic brain injury, major depression, and diffusion tensor imaging: Making connections

Maller, Jerome J., Thomson, Richard H. S., Lewis, Philip M., Rose, Stephen E., Pannek, Kerstin and Fitzgerald, Paul B. (2010) Traumatic brain injury, major depression, and diffusion tensor imaging: Making connections. Brain Research Reviews, 64 1: 213-240. doi:10.1016/j.brainresrev.2010.04.003

Author Maller, Jerome J.
Thomson, Richard H. S.
Lewis, Philip M.
Rose, Stephen E.
Pannek, Kerstin
Fitzgerald, Paul B.
Title Traumatic brain injury, major depression, and diffusion tensor imaging: Making connections
Journal name Brain Research Reviews   Check publisher's open access policy
ISSN 0165-0173
Publication date 2010-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.brainresrev.2010.04.003
Volume 64
Issue 1
Start page 213
End page 240
Total pages 8
Editor Floyd E. Bloom
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2011
Language eng
Formatted abstract
It is common for depression to develop after traumatic brain injury (TBI), yet despite poorer recovery, there is a lack in our understanding of whether post-TBI brain changes involved in depression are akin to those in people with depression without TBI. Modern neuroimaging has helped recognize degrees of diffuse axonal injury (DAI) as being related to extent of TBI, but its ability to predict long-term functioning is limited and has not been considered in the context of post-TBI depression. A more recent brain imaging technique (diffusion tensor imaging; DTI) can measure the integrity of white matter by measuring the directionality or anisotropy of water molecule diffusion along the axons of nerve fibers.

To review DTI results in the TBI and depression literatures to determine whether this can elucidate the etiology of the development of depression after TBI.

We reviewed the TBI/DTI (40 articles) and depression/DTI literatures (17 articles). No articles were found that used DTI to investigate depression post-TBI, although there were some common brain regions identified between the TBI/DTI and depression/DTI studies, including frontotemporal, corpus callosum, and structures contained within the basal ganglia. Specifically, the internal capsule was commonly reported to have significantly reduced fractional anisotropy, which agrees with deep brain stimulation studies.

It is suggested that measuring the degree of DAI by utilizing DTI in those with or without depression post-TBI, will greatly enhance prediction of functional outcome.

Keyword Traumatic brain injury
Magnetic resonance imaging
Diffusion tensor
Diffuse axonal injury
White matter
Late-life depression
Closed-head injury
White-matter abnormalities
Transcranial magnetic stimulation
Voxel-based morphometry
Dorsolateral prefrontal cortex
Mild cognitive impairment
II psychiatric-disorders
Cortical gray-matter
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 11 April 2010.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 38 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 49 times in Scopus Article | Citations
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Created: Sun, 18 Jul 2010, 00:08:41 EST