Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals

Ashauer, Roman, Caravatti, Ivo, Hintermeister, Anita and Escher, Beate I. (2010) Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals. Environmental Toxicology and Chemistry, 29 7: 1625-1636. doi:10.1002/etc.175


Author Ashauer, Roman
Caravatti, Ivo
Hintermeister, Anita
Escher, Beate I.
Title Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals
Formatted title
Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals
Journal name Environmental Toxicology and Chemistry   Check publisher's open access policy
ISSN 0730-7268
1552-8618
Publication date 2010-07-01
Sub-type Article (original research)
DOI 10.1002/etc.175
Volume 29
Issue 7
Start page 1625
End page 1636
Total pages 12
Editor C. H. Ward
Place of publication Houston, TX, U.S.A.
Publisher Society of Environmental Toxicology and Chemistry
Collection year 2011
Language eng
Subject 0399 Other Chemical Sciences
0599 Other Environmental Sciences
1199 Other Medical and Health Sciences
Formatted abstract
Uptake and elimination rate constants, bioaccumulation factors, and elimination times in the freshwater arthropod Gammarus pulex were measured for 14 organic micropollutants covering a wide range of hydrophobicity (imidacloprid, aldicarb, ethylacrylate, 4,6-dinitro-o-cresol, carbofuran, malathion, 4-nitrobenzyl-chloride, 2,4-dichloroaniline, Sea-Nine, 2,4-dichlorophenol, diazinon, 2,4,5-trichlorophenol, 1,2,3-trichlorobenzene, and hexachlorobenzene; all 14C-labeled). The toxicokinetic parameters were determined by least-square fitting of a one-compartment first-order toxicokinetic model, followed by Markov Chain Monte Carlo parameter estimation. The parameter estimation methods used here account for decreasing aqueous concentrations during the exposure phase or increasing aqueous concentrations during the elimination phase of bioaccumulation experiments. It is not necessary to keep exposure concentrations constant or zero during uptake and elimination, respectively. Neither is it required to achieve steady state during the exposure phase; hence, tests can be shorter. Prediction intervals, which take the between-parameter correlation into account, were calculated for bioaccumulation factors and simulations of internal concentrations under variable exposure. The lipid content of Gammarus pulex was 1.3% of wet weight, consisting of 25% phospholipids and 75% triglycerides. Size-dependent bioaccumulation was observed for eight compounds, although the magnitudes of the relationships were too small to be of practical relevance. Elimination times ranged from 0.45 to 20 d, and bioaccumulation factors ranged from 1.7 to 4,449 L/kg. The identified compounds with unexpectedly long elimination times should be given priority in future studies investigating the biotransformation of these compounds.
© 2010 SETAC.
Keyword Bioconcentration
Parameter estimation
Risk assessment
Toxicokinetic model
Ecological risk-assessment
Daphnia-magna
Dependent bioconcentration
Species sensitivity
Toxicity assessment
Aquatic organisms
Bayesian-approach
Hyalella-azteca
Body burdens
Exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
National Research Centre for Environmental Toxicology Publications
 
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Created: Sun, 18 Jul 2010, 10:07:30 EST