Microporous polycaprolactone matrices for drug delivery and tissue engineering: The release behaviour of bioactives having extremes of aqueous solubility

Chang, H.-I., Wang, Y., Perrie, Y. and Coombes, A. G. A. (2010) Microporous polycaprolactone matrices for drug delivery and tissue engineering: The release behaviour of bioactives having extremes of aqueous solubility. Journal of Drug Delivery Science and Technology, 20 3: 207-212.

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Author Chang, H.-I.
Wang, Y.
Perrie, Y.
Coombes, A. G. A.
Title Microporous polycaprolactone matrices for drug delivery and tissue engineering: The release behaviour of bioactives having extremes of aqueous solubility
Journal name Journal of Drug Delivery Science and Technology   Check publisher's open access policy
ISSN 1773-2247
1157-1489
Publication date 2010-05
Sub-type Article (original research)
Volume 20
Issue 3
Start page 207
End page 212
Total pages 6
Editor Elias Fattal
Place of publication Paris, France
Publisher Editions de Santes
Collection year 2011
Language eng
Formatted abstract
Microporous polycaprolactone (PCL) matrices loaded with hydrophobic steroidal drugs or a hydrophilic drug - pilocarpine hydrochloride - were produced by precipitation casting using solutions of PCL in acetone. The efficiency of steroid incorporation in the final matrix (progesterone (56%) testosterone (46%) dexamethasone (80%)) depended on the nature of the drug initially co-dissolved in the PCL solution. Approximately 90% w/w of the initial load of progesterone, 85% testosterone and 50% dexamethasone was released from the matrices in PBS at 37°C over 8 days. Pilocarpine hydrochloride (PH)-loaded PCL matrices, prepared by dispersion of powder in PCL solution, released 70-90% of the PH content over 12 days in PBS. Application of the Higuchi model revealed that the kinetics of steroid and PH release were consistent with a Fickian diffusion mechanism with corresponding diffusion coefficients of 5.8 × 10−9 (progesterone), 3.9 × 10 −9 (testosterone), 7.1 × 10−10 (dexamethasone) and 22 × 10−8 cm2/s (pilocarpine hydrochloride). The formulation techniques described are expected to be useful for production of implantable, insertable and topical devices for sustained delivery of a range of bioactive molecules of interest in drug delivery and tissue engineering.
Keyword Polycaprolactone
Microporous
Matrix device
Steroids
Pilocarpine
Ocular delivery
Tissue engineering
Marrow stromal cells
Transdermal delivery
Postmenopausal women
In-vivo
Dexamethasone
Poly(epsilon-caprolactone)
Progesterone
Dissolution
Gentamicin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published May-June 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Pharmacy Publications
 
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Created: Sun, 18 Jul 2010, 00:05:07 EST