Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital

Arden, KE, Chang, AB, Lambert, SB, Nissen, MD, Sloots, TP and Mackay, IM (2010) Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. Journal of Medical Virology, 82 8: 1458-1461. doi:10.1002/jmv.21819


Author Arden, KE
Chang, AB
Lambert, SB
Nissen, MD
Sloots, TP
Mackay, IM
Title Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital
Journal name Journal of Medical Virology   Check publisher's open access policy
ISSN 0146-6615
1096-9071
Publication date 2010-08
Year available 2010
Sub-type Article (original research)
DOI 10.1002/jmv.21819
Volume 82
Issue 8
Start page 1458
End page 1461
Total pages 4
Place of publication Hoboken, NJ, United States of America
Publisher John Wiley & Sons
Collection year 2011
Language eng
Subject 920115 Respiratory System and Diseases (incl. Asthma)
C1
060502 Infectious Agents
060506 Virology
970106 Expanding Knowledge in the Biological Sciences
Abstract There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) with the recovery from exacerbations in non-hospitalized asthmatic children (median age 5.1 years) were examined. Human rhinoviruses (HRVs) were present in 52.6% of specimens, HBoV-1 was in 7.7%. Viral co-detections occurred in 25.6% of children and were associated (P = 0.04) with lower asthma quality of life scores upon presentation than were single viral detections. The undifferentiated presence or absence of virus did not influence the severity of asthma or recovery however when virus species were examined individually, specific clinical associations emerged. HRV species C (HRV-Cs) were the viruses most frequently detected as single virus detections. Among 41 genotyped HRVs, more HRV-Cs (n = 23) were identified than HRV-As (n = 16) however HRV-A detection was associated (P = 0.01) with worse asthma symptoms and cough for longer than was HRV-C detection. Larger, PCR-based studies are required to elucidate further the true impact of HRV species in childhood asthma exacerbations of both hospitalized and non-hospitalized cohorts. J. Med. Virol. 82:1458–1461, 2010. © 2010 Wiley-Liss, Inc.
Keyword Asthma exacerbation
Rhinovirus
Human bocavirus-1
Respiratory infection
Human rhinovirus
Infections
Samples
PCR
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
Clinical Medical Virology Centre Publications
 
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Created: Sun, 18 Jul 2010, 00:04:09 EST