stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens

Cheng, Qin, Cloonan, Nicole, Fischer, Katja, Thompson, Jenny, Waine, Gary, Lanzer, Michael and Saul, Allan (1998) stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Molecular and Biochemical Parasitology, 97 1-2: 161-176. doi:10.1016/S0166-6851(98)00144-3


Author Cheng, Qin
Cloonan, Nicole
Fischer, Katja
Thompson, Jenny
Waine, Gary
Lanzer, Michael
Saul, Allan
Title stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
Formatted title
stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
Journal name Molecular and Biochemical Parasitology   Check publisher's open access policy
ISSN 0166-6851
Publication date 1998-11
Sub-type Article (original research)
DOI 10.1016/S0166-6851(98)00144-3
Volume 97
Issue 1-2
Start page 161
End page 176
Total pages 16
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 0604 Genetics
Formatted abstract
Several multicopy gene families have been described in Plasmodium falciparum, including the var genes that code for the variant surface antigen PfEMP1, the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. This report documents the chromosomal location of stevor genes, their transcription and characteristics of the deduced protein. On 14 chromosomes, 34 stevor copies were identified from the Dd2 parasite line. Most are in subtelomeric regions within 50 kb of the telomere. stevor genes are located close to var genes and rif. All stevor genes sequenced had two exons: a short exon 1 encoding a start codon and a transmembrane domain; exon 2 encoding for the remainder of the not, vert, similar30 kDa protein and including two more transmembrane segments. A similar structure was found for copies of rif and its predicted protein. In both STEVOR and RIF proteins, a highly polymorphic region is predicted to be a loop on the outer side of the membrane. We propose that stevor and rif are members of a larger superfamily. The number of copies of stevor and rif, their location close to the var genes, their extreme polymorphism and the predicted structure of the proteins suggest that stevor and rif code for variant surface antigens.
Keyword Plasmodium falciparum
Multicopy gene family
stevor
rif
var
Subtelomeric
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 14 Jul 2010, 16:39:19 EST by Laura McTaggart