Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats

Stranahan, Alexis M., Arumugam, Thiruma V., Lee, Kim and Mattson, Mark P. (2010) Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. Synapse, 64 7: 528-532. doi:10.1002/syn.20758

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Author Stranahan, Alexis M.
Arumugam, Thiruma V.
Lee, Kim
Mattson, Mark P.
Title Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats
Journal name Synapse   Check publisher's open access policy
ISSN 0887-4476
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1002/syn.20758
Volume 64
Issue 7
Start page 528
End page 532
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2011
Language eng
Abstract In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle. Diabetes mellitus increases levels of glucocorticoids in both humans and animal models. To explore the contributions of hippocampal corticosteroid receptors to the diabetes-induced suppression of neuroplasticity, we manipulated these receptors in hippocampal slices from streptozocin-diabetic rats, a model of Type 1 diabetes mellitus. STZ-diabetes reduced long-term potentiation (LTP) at medial perforant path synapses in the dentate gyrus, and induced a bias in favor of long-term depression following intermediate stimulation frequencies. Bath application of the mineralocorticoid receptor agonist aldosterone restored LTP in slices from diabetic animals. These results suggest additional mechanisms for diabetes-induced functional alterations and support a restorative role for dentate gyrus mineralocorticoid receptors. Copyright © 2010 Wiley-Liss, Inc.
Keyword Diabetes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 12 Jul 2010, 15:35:27 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences