Microsatellites provide evidence of Y-chromosome diversity among the founders of the New World

Ruiz Linares, Andres, Ortiz-Barrientos, Daniel, Figueroa, Mauricio, Mesa, Natalia, Munera, Juan G., Bedoya, Gabriel, Velez, Ivan D., Garcia, Luis F., Perez-Lezaun, Anna, Bertranpetit, Jaume, Feldman, Marcus W. and Goldstein, David B. (1999) Microsatellites provide evidence of Y-chromosome diversity among the founders of the New World. Proceedings of the National Academy of Sciences of the United States of America, 96 11: 6312-6317. doi:10.1073/pnas.96.11.6312


Author Ruiz Linares, Andres
Ortiz-Barrientos, Daniel
Figueroa, Mauricio
Mesa, Natalia
Munera, Juan G.
Bedoya, Gabriel
Velez, Ivan D.
Garcia, Luis F.
Perez-Lezaun, Anna
Bertranpetit, Jaume
Feldman, Marcus W.
Goldstein, David B.
Title Microsatellites provide evidence of Y-chromosome diversity among the founders of the New World
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 1999-05-25
Sub-type Article (original research)
DOI 10.1073/pnas.96.11.6312
Open Access Status Not Open Access
Volume 96
Issue 11
Start page 6312
End page 6317
Total pages 6
Place of publication Washington, D.C. U.S.A.
Publisher National Academy of Sciences of the U.S.A
Language eng
Subject 06 Biological Sciences
0699 Other Biological Sciences
Abstract Recently, Y chromosome markers have begun to be used to study Native American origins. Available data have been interpreted as indicating that the colonizers of the New World carried a single founder haplotype. However, these early studies have been based on a few, mostly complex polymorphisms of insufficient resolution to determine whether observed diversity stems from admixture or diversity among the colonizers. Because the interpretation of Y chromosomal variation in the New World depends on founding diversity, it is important to develop marker systems with finer resolution. Here we evaluate the hypothesis of a single-founder Y haplotype for Amerinds by using 11 Y-specific markers in five Colombian Amerind populations. Two of these markers (DYS271, DYS287) are reliable indicators of admixture and detected three non-Amerind chromosomes in our sample. Two other markers (DYS199, M19) are single-nucleotide polymorphisms mostly restricted to Native Americans. The relatedness of chromosomes defined by these two markers was evaluated by constructing haplotypes with seven microsatellite loci (DYS388 to 394). The microsatellite backgrounds found on the two haplogroups defined by marker DYS199 demonstrate the existence of at least two Amerind founder haplotypes, one of them (carrying allele DYS199 T) largely restricted to Native Americans. The estimated age and distribution of these haplogroups places them among the founders of the New World.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
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