An association study of bipolar mood disorder type I with the 5-HTTLPR serotonin transporter polymorphism in a population isolate from Colombia

Ospina-Duque, Jorge, Duque, Constanza, Carvajal-Carmona, Luis, Ortiz-Barrientos, Daniel, Soto, Ivan, Pineda, Nicolas, Cuartas, Mauricio, Calle, Jorge, Lopez, Carlos, Ochoa, Luis, Garcia, Jenny, Gomez, Juliana, Agudelo, Angela, Lozano, Maria, Montoya, Gabriel, Ospina, Angelica, Lopez, Maria, Gallo, Aurora, Miranda, Ana, Serna, Lina and et al (2000) An association study of bipolar mood disorder type I with the 5-HTTLPR serotonin transporter polymorphism in a population isolate from Colombia. Neuroscience Letters, 292 3: 199-202. doi:10.1016/S0304-3940(00)01464-6


Author Ospina-Duque, Jorge
Duque, Constanza
Carvajal-Carmona, Luis
Ortiz-Barrientos, Daniel
Soto, Ivan
Pineda, Nicolas
Cuartas, Mauricio
Calle, Jorge
Lopez, Carlos
Ochoa, Luis
Garcia, Jenny
Gomez, Juliana
Agudelo, Angela
Lozano, Maria
Montoya, Gabriel
Ospina, Angelica
Lopez, Maria
Gallo, Aurora
Miranda, Ana
Serna, Lina
et al
Title An association study of bipolar mood disorder type I with the 5-HTTLPR serotonin transporter polymorphism in a population isolate from Colombia
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2000-01-01
Sub-type Article (original research)
DOI 10.1016/S0304-3940(00)01464-6
Volume 292
Issue 3
Start page 199
End page 202
Total pages 4
Place of publication Ireland
Publisher Elsevier Science
Language eng
Subject 0604 Genetics
1109 Neurosciences
Abstract The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N=103) / control (N=112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant.
Keyword Serotonin transporter
Bipolar mood disorder
Population isolates
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
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Created: Mon, 12 Jul 2010, 19:11:05 EST by Laura McTaggart on behalf of Faculty of Science