ADAM28: A potential oncogene involved in asbestos-related lung adenocarcinomas

Wright, CM, Larsen, JE, Hayward, NK, Martins, MU, Tan, ME, Davidson, MR, Savarimuthu, SM, McLachlan, RE, Passmore, LH, Windsor, MN, Clarke, BE, Duhig, EE, Yang, IA, Bowman, RV and Fong, KM (2010) ADAM28: A potential oncogene involved in asbestos-related lung adenocarcinomas. Genes Chromosomes & Cancer, 49 8: 688-698.

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Author Wright, CM
Larsen, JE
Hayward, NK
Martins, MU
Tan, ME
Davidson, MR
Savarimuthu, SM
McLachlan, RE
Passmore, LH
Windsor, MN
Clarke, BE
Duhig, EE
Yang, IA
Bowman, RV
Fong, KM
Title ADAM28: A potential oncogene involved in asbestos-related lung adenocarcinomas
Journal name Genes Chromosomes & Cancer   Check publisher's open access policy
ISSN 1045-2257
1098-2264
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1002/gcc.20779
Volume 49
Issue 8
Start page 688
End page 698
Total pages 11
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2011
Language eng
Formatted abstract Asbestos-related lung cancer accounts for 4–12% of all lung cancers worldwide. Since putative mechanisms of carcinogenesis differ between asbestos and tobacco induced lung cancers, tumors induced by the two agents may be genetically distinct. To identify gene expression biomarkers associated with asbestos-related lung tumorigenicity we performed gene expression array analysis on tumors of 36 patients with primary lung adenocarcinoma, comparing 12 patients with lung asbestos body counts above levels associated with urban dwelling (ARLC-AC: asbestos-related lung cancer-adenocarcinoma) with 24 patients with no asbestos bodies (NARLC-AC: non-asbestos related lung cancer-adenocarcinoma). Genes differentially expressed between ARLC-AC and NARLC-AC were identified on fold change and P value, and then prioritized using gene ontology. Candidates included ZNRF3, ADAM28, PPP1CA, IRF6, RAB3D, and PRDX1. Expression of these six genes was technically and biologically replicated by qRT-PCR in the training set and biologically validated in three independent test sets. ADAM28, encoding a disintegrin and metalloproteinase domain protein that interacts with integrins, was consistently upregulated in ARLC across all four datasets. Further studies are being designed to investigate the possible role of this gene in asbestos lung tumorigenicity, its potential utility as a marker of asbestos related lung cancer for purposes of causal attribution, and its potential as a treatment target for lung cancers arising in asbestos exposed persons. © 2010 Wiley-Liss, Inc.
Keyword Factor binding protein-3
Lymph-node metastasis
Gene-expression
Cell-proliferation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 11 Jul 2010, 00:05:57 EST