Quality of life in children with crohn disease

Hill, R. J., Lewindon, P. J., Muir, R., Grange, I., Connor, F. L., Ee, L. C., Withers, G. D., Cleghorn, G. J. and Davies, P. S. W. (2010) Quality of life in children with crohn disease. Journal of Pediatric Gastroenterology and Nutrition, 51 1: 35-40. doi:10.1097/MPG.0b013e3181c2c0ef

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Author Hill, R. J.
Lewindon, P. J.
Muir, R.
Grange, I.
Connor, F. L.
Ee, L. C.
Withers, G. D.
Cleghorn, G. J.
Davies, P. S. W.
Title Quality of life in children with crohn disease
Journal name Journal of Pediatric Gastroenterology and Nutrition   Check publisher's open access policy
ISSN 0277-2116
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1097/MPG.0b013e3181c2c0ef
Volume 51
Issue 1
Start page 35
End page 40
Total pages 6
Place of publication Maryland, MO, U.S.A.
Publisher Lippincott Williams and Wilkins
Collection year 2011
Language eng
Subject 1103 Clinical Sciences
1111 Nutrition and Dietetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Quality of life (QOL) is reportedly poor in children with Crohn disease (CD) but improves with increasing disease duration. This article aims to detail QOL in a cohort of Australian children with CD in relation to disease duration, disease activity, and treatment.

Materials and Methods:
QOL, assessed using the IMPACT-III questionnaire, and disease activity measures, assessed using the Pediatric Crohn's Disease Activity Index (PCDAI), were available in 41 children with CD. For this cohort, a total of 186 measurements of both parameters were available.


QOL was found to be significantly lower, and disease activity significantly higher (F = 31.1, P = 0.00), in patients within 6 months of their diagnosis compared with those up to 2.5 years, up to 5 years, and beyond 5 years since diagnosis. Higher disease activity was associated with poorer QOL (r =-0.51, P = 0.00). Total QOL was highest in children on nil medications and lowest in children on enteral nutrition. The PCDAI (t =-6.0, P = 0.00) was a significant predictor of QOL, with the clinical history (t =-6.9, P = 0.00) and examination (t =-2.9, P = 0.01) sections of the PCDAI significantly predicting QOL. Disease duration, age, or sex was neither related to nor significant predictors of QOL, but height z score and type of treatment approached significance.


Children with CD within 6 months of their diagnosis have impaired QOL compared with those diagnosed beyond 6 months. These patients, along with those with growth impairment, ongoing elevated disease activity with abdominal pain, diarrhoea and/or perirectal and extraintestinal complications, may benefit from regular assessments of QOL as part of their clinical treatment. © 2010 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Keyword Children
Crohn disease
Disease activity
Disease duration
Quality of life
Type of treatment
Activity Index
1ST Year
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 11 Jul 2010, 00:03:28 EST