RESULTS OF LONG-TERM FOLLOW-UP AFTER COMPENSATED FIXED-DOSE THERAPY FOR THYROTOXICOSIS

ZAINI, A, KHIR, A, DOI, SAR, CHAN, SP, PARAMSOTHY, M and KHOO, BH (1992) RESULTS OF LONG-TERM FOLLOW-UP AFTER COMPENSATED FIXED-DOSE THERAPY FOR THYROTOXICOSIS. Journal of International Medical Research, 20 3: 279-288. doi:10.1177/030006059202000310

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Author ZAINI, A
KHIR, A
DOI, SAR
CHAN, SP
PARAMSOTHY, M
KHOO, BH
Title RESULTS OF LONG-TERM FOLLOW-UP AFTER COMPENSATED FIXED-DOSE THERAPY FOR THYROTOXICOSIS
Journal name Journal of International Medical Research   Check publisher's open access policy
ISSN 0300-0605
1473-2300
Publication date 1992-06
Sub-type Article (original research)
DOI 10.1177/030006059202000310
Open Access Status File (Publisher version)
Volume 20
Issue 3
Start page 279
End page 288
Total pages 10
Place of publication Worthing, U.K.
Publisher Field House Publishing
Language eng
Abstract To evaluate the effects of simple compensated fixed-dose iodine-131 therapy for thyrotoxicosis, the long-term results for 74 patients treated with a fixed dose of iodine-131 ranging from 5 to 12 mCi (185 to 444 MBq) were evaluated in the first 2 years of a trial. The dose selected was loosely based on the gross size of the thyroid gland. Routine antithyroid drug therapy was given for a minimum of 3 months after iodine-131 therapy. The mean (+/- SD) duration of follow-up was 74.5 +/- 42 months. The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131. Of those cured using a single iodine-131 dose, 81% were no longer receiving drugs after 6 months and 85% after 1 year. Such a regimen seems currently to be among the best available where prolonged periods of medication-free euthyroidism after therapy are sought.
Keyword I-131
THYROTOXICOSIS
GOITER
HYPOTHYROIDISM
ABLATIVE RADIOIODINE THERAPY
GRAVES-DISEASE
I-131 THERAPY
HYPERTHYROIDISM
GOITER
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 07 Jul 2010, 10:18:55 EST