Sociedad Iberoamericana de Informacion Cientifica (S I I C)
We believe that there are three clinical phenotypes of PCOS that represent distinct forms of the same metabolic disorder and that are the result of varying degrees of metabolic dysfunction. Patients with neuroendocrine dysfunction and irregular cycles (phenotype A) had the mildest degrees of hyperinsulinemia in contrast to patients with phenotype B (irregular cycles without neuroendocrine dysfunction) who demonstrated the greatest degrees of hyperinsulinemia. Regularly cycling women, who do not manifest neuroendocrine dysfunction (phenotype C), appeared to have intermediate degrees of hyperandrogenemia and metabolic dysfunction. These data suggest that the clinical phenotype can be useful to decide on therapy and may arise, at least in part, from differences in the degree of metabolic dysfunction.