Review: Sex specific programming: A critical role for the renal renin-angiotensin system

Moritz, K.M., Cuffe, J. S., Wilson, L. B., Dickinson, H., Wlodek, M. E., Simmons, D. G. and Denton, K. M. (2010). Review: Sex specific programming: A critical role for the renal renin-angiotensin system. In: D. Michael Nelson and Graham J. Burton, Placenta : The Key to Pregnancy Success. Annual Meeting of the International Federationof Placenta Associations, Adelaide, South Australia, (S40-S46). 6-9 October, 2009. doi:10.1016/j.placenta.2010.01.006

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Author Moritz, K.M.
Cuffe, J. S.
Wilson, L. B.
Dickinson, H.
Wlodek, M. E.
Simmons, D. G.
Denton, K. M.
Title of paper Review: Sex specific programming: A critical role for the renal renin-angiotensin system
Conference name Annual Meeting of the International Federationof Placenta Associations
Conference location Adelaide, South Australia
Conference dates 6-9 October, 2009
Proceedings title Placenta : The Key to Pregnancy Success   Check publisher's open access policy
Journal name Placenta   Check publisher's open access policy
Place of Publication London, England
Publisher W.B. Saunders
Publication Year 2010
Sub-type Fully published paper
DOI 10.1016/j.placenta.2010.01.006
ISSN 0143-4004
Editor D. Michael Nelson
Graham J. Burton
Volume 31
Issue Suppl. 1
Start page S40
End page S46
Total pages 7
Collection year 2011
Language eng
Abstract/Summary The "Developmental Origins of Health and Disease" hypothesis has caused resurgence of interest in understanding the factors regulating fetal development. A multitude of prenatal perturbations may contribute to the onset of diseases in adulthood including cardiovascular and renal diseases. Using animal models such as maternal glucocorticoid exposure, maternal calorie or protein restriction and uteroplacental insufficiency, studies have identified alterations in kidney development as being a common feature. The formation of a low nephron endowment may result in impaired renal function and in turn may contribute to disease. An interesting feature in many animal models of developmental programming is the disparity between males and females in the timing of onset and severity of disease outcomes. The same prenatal insult does not always affect males and females in the same way or to the same degree. Recently, our studies have focused on changes induced in the kidney of both the fetus and the offspring, following a perturbation during pregnancy. We have shown that changes in the renin-angiotensin system (RAS) occur in the kidney. The changes are often sex specific which may in part explain the observed sex differences in disease outcomes and severity. This review explores the evidence suggesting a critical role for the RAS in sex specific developmental programming of disease with particular reference to the immediate and long term changes in the local RAS within the kidney. © 2010 Elsevier Ltd. All rights reserved.
Subjects C1
920114 Reproductive System and Disorders
0606 Physiology
Keyword Developmental programming
Nephron number
Renin-angiotensin system
sex differences
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Created: Tue, 06 Jul 2010, 11:09:26 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences